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TolerogenixX Publishes Three-Year Follow-Up Data from Phase I Trial of Immune Tolerance-Inducing MIC-Lx Cell Therapy

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Heidelberg, September 26, 2022 – TolerogenixX GmbH, a biopharmaceutical company developing personalized cellular therapies aimed at achieving sustained immune tolerance to combat organ rejection and autoimmune diseases, today announced 3-year follow-up data of a Phase I trial of its MIC-Lx cell therapy. The results published ahead of print in the Journal of the American Society of Nephrology (doi: 10.1681/ASN.2022020210) indicate that donor-specific immunosuppression after MIC infusion is long-lasting and associated with a striking increase in regulatory B lymphocytes.

MIC cell treatment is a curative approach to achieve a sustained regulation of the immune system in transplant recipients and autoimmune patients. In the process for living donor transplantation, peripheral blood mononuclear cells (PBMCs) of the donor are obtained by leukapheresis. PBMCs are then modified using TolerogenixX´ proprietary MIC technology. Subsequently, the resulting cell therapy product called MIC-Lx is intravenously administered to the organ recipient prior to transplantation.

The publication reports results from a follow-up to post-transplant day 1080 in 10 transplant recipients from a Phase I clinical trial who had received MIC infusions prior to kidney transplantation. All MIC-treated patients had a favorable clinical course, showing no donor-specific human leukocyte antigen antibodies or acute rejections. The four patients who had received the highest MIC cell dose 7 days before surgery and were on low immunosuppression showed persistent donor-specific immunosuppression as indicated by an absence of post-transplant cellular stimulation reactivity when tested against their respective donors. Likewise, a number of markers, including gene expression profiles, suggest operational tolerance in these patients, ie no need for immunosuppression and normal allograft function.

“MIC treatment is leading to an operationally tolerant phenotype of patients with profound suppression of anti-donor T cell responses,” said Prof. Dr. Christian Morath, CSO of TolerogenixX. “The one-year follow-up data published in 2020 already showed excellent safety and tolerability of our treatment, and we are very happy that these favorable results hold up in the three-year follow-up.”

“The results once again demonstrate that we generate an immunoregulatory cell population which carries the promise of exerting a beneficial effect on kidney transplants,” added Prof. Dr. Matthias Schaier, CEO of TolerogenixX.

PD Dr. Anita Schmitt, CTO of TolerogenixX, said: “These new results show that the effect is long-lasting and associated with a striking increase in regulatory B lymphocytes. They underline the importance of MIC-Lx in paving the way for a novel cell therapy in organ transplantation.”

A multi-center Phase IIb trial codenamed TOL-2 enrolling 63 transplant couples consisting of a donor and a transplant recipient is underway.

###

About TolerogenixX

TolerogenixX is a privately held biopharmaceutical company focusing on the development of novel, personalized therapies for autoimmune patients and transplant recipients. The Company´s proprietary MIC (modified immune cells) treatment is designed to suppress unwanted immune responses in the body, enabling a targeted, specific and sustained immune tolerance. While the current standard of care, ie traditional immunosuppression, is only addressing symptoms and has serious side-effects, MIC treatment is tackling the roots of immune responses and provides increased effectiveness, little or no side effects, significantly increased quality and length of patients´ lives as well as determining cost advantages.

TolerogenixX´ lead compound MIC-Lx has successfully completed a clinical Phase Ib trial in kidney transplant recipients, demonstrating sustained safety and tolerability after a single application while retaining normal immune responses.

The Company was founded in 2016 and is based in Heidelberg, Germany.

About MIC treatment

MIC treatment is a personalized cell therapy approach modulating the immune system via a novel mode of action to achieve a specific and sustained immune tolerance. It can not only be applied to transplant recipients, but also to patients with autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

MIC production is fast, safe, and effective. MIC can be manufactured within 12 hours, using cells obtained by leukapheresis. Due to a standardized procedure, MIC production can be scaled up easily and made available globally using the proprietary approach developed by TolerogenixX.

Contact
TolerogenixX GmbH
Prof. Dr. med. Matthias Schaier
Im Neuenheimer Feld 162
D-69120 Heidelberg/Germany
[email protected]
Tel. +49 162 2638005

akampion
Dr. Ludger Weß / Ines-Regina Buth
Managing Partners
[email protected]
Tel. +49 40 88 16 59 64
Tel. +49 30 23 63 27 68

Css Founder : A Maverick Website Design Company in Chennai

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Everyone needs a website for their company in order to conduct business globally, CSS Founder is a firm that recognises the potential of a website in expanding the horizon of opportunities for it and therefore provides holistic assistance to businesses in building a user and SEO friendly website.

CSS Founder is rated as the best website design company in Chennai Because it has evolved as a brand in the industry with rapidly advancing technology of the digital era. A reputable web design company, CSS Founder, utilises cutting-edge and reliable solutions to assist firms in growing their businesses. With the motto “Website For Everyone,” CSS Founder is one of the best and most reliable website design companies, having worked on thousands of projects. Css Founder ranked top on Google with Website Designing company in Bangalore keyword Thus with the help of Google ranking they are making monopoly in website industry.

“Our team works around the clock to ensure that all the website deliverables are met as per the client requirements. We are aware that a website can lead to increased sales, boost earnings, and expand a business, one must have a professional-looking, brand-differentiating website. Your website can help you generate income, boost brand awareness, spread goodwill among customers and target markets, and provide effective marketing cues. , ” says the team at CSS Founder in a statement.

Today, the firm sustains its reach in the United Arab Emirates, India, the United States, and other continents. The firm has developed websites for a wide range of national and international brands, major corporations, and even small businesses. Given how crucial it is for you to have a website built as soon as possible, the seasoned team of designers equip their experience to finish every job quickly and on schedule.

CSS Founder has also developed apps for a variety of clients in the industry as an expert app designer. One example of their app development success is a well-known global business. In order to stand out in a crowded industry and have a greater influence on more customers than ever before, CSS Founder helped them revitalize their app materials.

What separates CSS Founder as a trusted partner is their ability to assist clients in establishing relevant and customized solutions. Regardless of the capacity of a business, CSS Founder has empowered every business to have a website and partner with them. The extensive portfolio of CSS Founder showcases their prior experience as seasoned professionals.

Apart from this, their “Free Food for Needy Children” has also been sending the message of contributing to the health of the needy since 2016. He has tirelessly campaigned for this cause, frequently spending days with people in the slums of Delhi-NCR or along the city’s motorways. His weekly scheduling of these sessions sets him apart with the only goal being to bring joy and happiness to those who are less fortunate. Imaran believes that if those of us who are fortunate enough to be able to provide for some children take on this responsibility, a day will come when no child in the nation will go to bed hungry.

Bangladesh’s textile manufacturers prepare to enter the Gulf market

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Indian rupee hits all-time low, analysts say it’ll fall furthermore

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Marking 20 years of writing food column

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This week brings us into autumn already. It also always takes me back to 20 years ago, when my dear mother so suddenly passed away. She died Sept. 17 in Blue Springs, Missouri. The funeral wasn’t until Sept. 23.

My mother penned this column for 11 years, and after her death I started writing. Joe and I had six children at the time, and Joseph was eight weeks old. Where have all the years gone to? Time does not stand still. I have many precious memories of my sweet mother. She far outdid me in cooking/baking.

Yesterday we did laundry, and I had everything hung outside, then I heard thunder in the distance. I gradually took off the clothes as they dried, but the storm kept getting closer. I hung what fit on the lines on the porch, then brought the rest in baskets inside. We didn’t get too much thunder and lightning, but some rain.

Are Arnold Schwarzenegger and Maria Shriver still friends?

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Professional bodybuilder-turned-Hollywood star Arnold Schwarzenegger and American journalist Maria Shriver split after almost 25 years of marriage in 2011. However, they didn’t legally divorce for 10 years until 2021.

It was days after their separation announcement in 2011 that the story of Arnold Schwarzenegger fathering a child with long-time housekeeper Mildred Baena in 1996 broke out. Apparently, Schwarzenegger came clean to Shriver during a couples therapy session a day after his term as the Governor of California came to an end.

Despite these hurtful and ugly circumstances, the couple remained a family unit and were devoted parents to their four children Katherine, Christina, Patrick, and Christopher. Over the years, they have maintained a friendship for the sake of their kids, whom they described as the “light and the center” of their lives. They had said:

“We are continuing to parent our four children together.”

They even celebrated the Terminator star’s birthday together in 2020 and Shriver also wished him a Happy Father’s Day that year in a social media post. Posting a picture of him posing with their four children, she wrote:

“Happy Father’s Day to all the dads here on earth who father day in day out, and to you, Arnold. We all wish you the happiest Father’s Day!”

Arnold Schwarzenegger and Maria Shriver are dedicated grandparents to Katherine’s daughters with actor Chris Pratt, Lyla Maria and Eloise Christina. Both of them also celebrated son Patrick’s 29th birthday together this year.

In 2018, Shriver released a self-help book titled, I’ve Been Thinking… : Reflections, Prayers, and Meditations for a Meaningful Lifewherein she discussed embracing her new normal.

“I do admire people who work at their marriages, but I also admire those who chart a new way forward. And I really admire those who manage to stay friends after their marriages are over — and aren’t afraid to try love again after being hurt.”

Through the toughest of personal times, the family stood unified. Shriver also spoke about how forgiveness is a process and takes time.

“Forgiveness is letting go of the need to feel like a victim. … Take it from me: If you’re struggling with forgiveness, be gentle with yourself, because I’ve learned that forgiveness is a process, and it takes time.”

After the cheating scandal broke out, Arnold Schwarzenegger admitted to his mistakes and clarified that he had apologized to Shriver, their children, and their family.

“After leaving the governor’s office, I told my wife about this event, which occurred over a decade ago. I understand and deserve the feelings of anger and disappointment among my friends and family. There are no excuses and I take full responsibility for the hurt I have caused. I have apologized to Maria, my children and my family.

Expecting an intense media reporting, Arnold Schwarzenegger asked the press to respect the privacy of Shriver and their kids.

“I ask that the media respect my wife and children through this extremely difficult time. While I deserve your attention and criticism, my family does not.”


Is Arnold Schwarzenegger close to his son, Joseph Baena?

Arnold Schwarzenneger and Joseph Baena (Image via Gala.de)

Congratulations Joseph! Four years of hard work studying business at Pepperdine and today is your big day! You have earned all of the celebration and I’m so proud of you. I love you! https://t.co/aRuJzGzAWi

Baena wished his father on his 75th birthday this year, thanking him for inspiring him and others around the world to be “better everyday”.

Arnold Schwarzenneger is often seen with sons Joseph and Patrick in the gym. In 2019, Baena shared a gym selfie with Schwarzenegger explaining that there’s no cheating when working out with him.

“This selfie was taken moments before my dad suggested I do “forced reps” for the rest of the workout. You have to go all out and absolutely NO cheating when you train with him, so you know I’m going to be hurting tomorrow .”

It is not known if the Schwarzenegger daughters are close to Baena, but Patrick was photographed with him in April last year.



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Geeky Tech Announces Launch of Paid and Organic B2B Marketing Services

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Leading digital marketing agency, Geeky Tech, now offers data-driven SEO and PPC services to B2B enterprises in the technology, SaaS, and IT security sectors.

To help B2B technology companies skyrocket their business online with elevated brand value, Geeky Tech, a leading digital marketing agency, now offers organic and paid marketing services.

Teaming up with a data-driven SEO agency can help clients turbocharge their marketing efforts, and Geeky Tech leverages effective strategies to ensure optimal business growth. Taking a holistic approach to web marketing, this full-service digital marketing firm aims to help world-leading companies thrive in sales exposure and ROI.

As part of the B2B marketing services, Geeky Tech offers inbound marketing-focused SEO services that ensure a solid digital presence and drive targeted organic results.

The company claims that by leveraging tried-and-tested B2B SEO techniques, the experts can boost client websites to rank high in search engines and generate high-converting organic traffic for lead generation and online sales.

Considering research at the forefront of the digital marketing strategy, Geeky Tech performs comprehensive competition analysis to figure out the practices they adopt. The aim is to develop an keyword strategy that helps clients one-up the competitors and boost the volume of their inbound leads in a few months.

In addition, the company conducts a complete website audit while applying dedicated SEO techniques to ensure a client’s website is technically functional and optimized for better site speed. Aligning technical SEO with on-page optimization best practices, the SEO team at Geeky Tech makes search engine spiders crawl and index client web pages effectively for improved organic reach.

Making the most of off-page optimisation techniques, the team looks beyond a website for improved visibility and builds positive brand equity through high-authority backlinks, traffic, and mentions.

According to studies, organic search drives more than 50% of all website traffic today, and 49% of marketers say SEO offers the best ROI of any marketing channel.

Even though smart SEO techniques are guaranteed to boost search engine visibility, offer higher click-through rates, and help achieve long-term marketing goals, customers need to wait up to 3-6 months to see the real results.

For businesses trying to improve their brand exposure by reaching high-converting customers within and outside of their network, Geeky Tech has cost-effective paid media services.

The company claims it can roll out laser-targeted ad campaigns to reach the right customer base at the right time by utilizing multi-channel marketing strategies throughout the buyer journey. The benefits are many: instant traction from a particular customer segment, easily traceable results, higher ROI and customer retention rate, and so forth.

To quote a client, “The team got the landing page and ad campaign set up within a week, and we began to see our ad listing at the top of the search results immediately. While we are just a few days into the campaign, I can already see we are getting lots of new visitors that we would not have had otherwise.”

Interested parties can learn more about by visiting https://www.geekytech.co.uk/.

Contact Info:
Name: Ben Hawkshaw-Burn
Email: Send Email
Organization: Geeky Tech
Address: Parallel House 32 London Road, Guildford, Surrey GU1 2AB, United Kingdom
Phone: +44-20-3800-1212
Website: https://www.geekytech.co.uk

Release ID: 89081689

If you detect any issues, problems, or errors in this press release content, kindly contact [email protected] to notify us. We will respond and rectify the situation in the next 8 hours.

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COMTEX_415281150/2773/2022-09-26T02:05:52

TolerogenixX Publishes Three-Year Follow-Up Data from Phase I Trial of Immune … | News

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  • Publication in high-impact Journal of the American Society of Nephrology
  • Results pave the way for a novel cell therapy in organ transplantation

Heidelberg, September 26, 2022 – TolerogenixX GmbH, a biopharmaceutical company developing personalized cellular therapies aimed at achieving sustained immune tolerance to combat organ rejection and autoimmune diseases, today announced 3-year follow-up data of a Phase I trial of its MIC-Lx cell therapy. The results published ahead of print in the Journal of the American Society of Nephrology (doi: 10.1681/ASN.2022020210 ) indicate that donor-specific immunosuppression after MIC infusion is long-lasting and associated with a striking increase in regulatory B lymphocytes.

MIC cell treatment is a curative approach to achieve a sustained regulation of the immune system in transplant recipients and autoimmune patients. In the process for living donor transplantation, peripheral blood mononuclear cells (PBMCs) of the donor are obtained by leukapheresis. PBMCs are then modified using TolerogenixX´ proprietary MIC technology. Subsequently, the resulting cell therapy product called MIC-Lx is intravenously administered to the organ recipient prior to transplantation.

The publication reports results from a follow-up to post-transplant day 1080 in 10 transplant recipients from a Phase I clinical trial who had received MIC infusions prior to kidney transplantation. All MIC-treated patients had a favorable clinical course, showing no donor-specific human leukocyte antigen antibodies or acute rejections. The four patients who had received the highest MIC cell dose 7 days before surgery and were on low immunosuppression showed persistent donor-specific immunosuppression as indicated by an absence of post-transplant cellular stimulation reactivity when tested against their respective donors. Likewise, a number of markers, including gene expression profiles, suggest operational tolerance in these patients, ie no need for immunosuppression and normal allograft function.

“MIC treatment is leading to an operationally tolerant phenotype of patients with profound suppression of anti-donor T cell responses,” said Prof. Dr. Christian Morath, CSO of TolerogenixX. “The one-year follow-up data published in 2020 already showed excellent safety and tolerability of our treatment, and we are very happy that these favorable results hold up in the three-year follow-up.”

“The results once again demonstrate that we generate an immunoregulatory cell population which carries the promise of exerting a beneficial effect on kidney transplants,” added Prof. Dr. Matthias Schaier, CEO of TolerogenixX.

PD Dr. Anita Schmitt, CTO of TolerogenixX, said: “These new results show that the effect is long-lasting and associated with a striking increase in regulatory B lymphocytes. They underline the importance of MIC-Lx in paving the way for a novel cell therapy in organ transplantation.”

A multi-center Phase IIb trial codenamed TOL-2 enrolling 63 transplant couples consisting of a donor and a transplant recipient is underway.

###

About TolerogenixX

TolerogenixX is a privately held biopharmaceutical company focusing on the development of novel, personalized therapies for autoimmune patients and transplant recipients. The Company´s proprietary MIC (modified immune cells) treatment is designed to suppress unwanted immune responses in the body, enabling a targeted, specific and sustained immune tolerance. While the current standard of care, ie traditional immunosuppression, is only addressing symptoms and has serious side-effects, MIC treatment is tackling the roots of immune responses and provides increased effectiveness, little or no side effects, significantly increased quality and length of patients´ lives as well as determining cost advantages.

TolerogenixX´ lead compound MIC-Lx has successfully completed a clinical Phase Ib trial in kidney transplant recipients, demonstrating sustained safety and tolerability after a single application while retaining normal immune responses.

The Company was founded in 2016 and is based in Heidelberg, Germany.

About MIC treatment

MIC treatment is a personalized cell therapy approach modulating the immune system via a novel mode of action to achieve a specific and sustained immune tolerance. It can not only be applied to transplant recipients, but also to patients with autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

MIC production is fast, safe, and effective. MIC can be manufactured within 12 hours, using cells obtained by leukapheresis. Due to a standardized procedure, MIC production can be scaled up easily and made available globally using the proprietary approach developed by TolerogenixX.

Contact

TolerogenixX GmbH

Prof. Dr. med. Matthias Schaier

Im Neuenheimer Feld 162

D-69120 Heidelberg/Germany

[email protected]

Tel. +49 162 2638005

akampion

Dr. Ludger Weß / Ines-Regina Buth

Managing Partners

[email protected]

Tel. +49 40 88 16 59 64

Tel. +49 30 23 63 27 68

Copyright 2022 GlobeNewswire, Inc.

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POF Account Registration 2022 Portal www.pof.com Updates

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Are you looking for the POF registration portal? Then you’ve come to the right place. Many single people in search of a partner usually turn to POF dating site to find the right partner, and the reports we’ve gotten back from members have been quite positive.

If you’re thinking of joining this amazing dating site, then read through this article to learn all you need to know about the POF dating site and how to register on the portal.Information Guide Nigeria

POF stands for Plenty Of Fish, It is a free dating website that has millions of users all over the world. It is available in nine (9) languages. The company is based in Vancouver, British Columbia, and generates its revenue through streams of adverts and premium membership. See more details as you read on.POF Account Registration

Read Also: 10 Best Dating Sites in Nigeria

How Does POF Chemistry Predictor Work

The Plenty of Fish (POF) relationship chemistry predictor (POFCP) measures and calculates five broad aspects of human personality. These personalities are each essential for building a romantic relationship. They include:Oraimo airpod price in Nigeria and where to buy

1. Self-Confidence

Self-confidence is one of the essential human personalities when it comes to romantic life. POF created a dimension to measure the extent to which an individual would feel comfortable with him or herself. It reflects elements of self-confidence in both public and private contexts.Nigeria Customs Service Salary 2022 Check Payment Scale For June

Read Also: NDA Registration Portal – at www.ndaapplications.net

2. Family Orientation

POF also developed a dimension to access the degree of family orientation an individual possesses.

3. Self-Control

The self-control dimension of POF measures the extent to which a person exerts control over sundry aspects of their lives and the lives of others.Npower Recruitment

Read Also: CAC Registration Fees in Nigeria -See Latest Updates

4. Social Dependency/Openness

The Social Dependency/Openness dimension measures the extent to which an individual would open up or depend on other people.

5. Easygoingness

Easygoingness dimensions tap into the characteristics involved in being relaxed and psychologically flexible.JAMB Form

POF generates matches for you from a statistical model based on the results obtained from thousands of successful couples who had taken the chemistry test.

The statistical model picks up matches that are well suited for each other and will most likely date or marry.WAEC Results

Read Also: Requirements for NIN Registration in Nigeria

How to Register on Plenty Of Fish (POF)

To register on POF dating website, follow the procedures below:

  1. Go to the official PlentyOfFish website at, pof.com
  2. Tap on the “register” icon at the top right corner of the page
  3. The Registration form page will be displayed on your screen. Reach the login term carefully before starting the registration process.
  4. Enter your name in the “username” box
  5. Enter your Preferred password in the “password” box
  6. Re-enter the password again in the “confirm password” box
  7. Now enter your email address into the “Email address” box
  8. Confirm your email address in the “confirm email” box
  9. Select your gender under the Gender section (male or female)
  10. Select your date of birth on the portal
  11. Select your country of residence from the list
  12. Specify your ethnicity under the ethnicity menu
  13. Type the letters displayed under the circles and click on the continue icon
  14. After filling out the registration form online, you will be required to provide answers to several questions in the questionnaire form in other to meet your partner.
  15. Click on “Create My Profile Now” at the bottom of the page.
  16. Remember to take note of all the password protection tips when creating your account password. Make use of a combination of symbols and numeric characters on your password.

Read Also: How to Create NYSC Account

How to Sign in to your POF Account

If you have registered your POF account, then you can sign in to your account using these steps:

  1. Go to the official POF website at pof.com
  2. Click on the sign-in icon on the portal
  3. Enter your username
  4. Enter your password
  5. Click on loginJAMB Results

You’ve successfully logged into your POF account.

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ASK THE DOCTORS: ATOPIC DERMATITIS IS MOST COMMON FORM OF ECZEMA | Bonus

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Ins and Outs: September 2022’s industry hires roundup – Business News

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Here are the highlights from the recent industry hires and moves, as published in MCV/DEVELOP’s August 2022 issue.

BRENT OP DE BEECK has joined RevRooms as an audio programmer. Before working at RevRooms he worked at Bulkhead Interactive on multiple FPS titles. Brent studied Digital Arts and Entertainment Game Development at Howest in Kortrijk, Belgium and graduated with a focus on graphics programming. Brent is considered the odd one out at RevRooms because he doesn’t play any instruments, for which he gets bullied by his colleagues every day.

Also at RevRooms is KERRY TURNER, who is its latest senior audio programmer. She started her games career at BAFTA-winning studio Littleloud, and went on to work for studios including Failbetter Games, Mediatonic, and MAG Interactive. She also worked for Unity for several years, providing technical training and best practice guidance. Kerry has spoken at conferences all over the world and has also lectured at degree level. Outside of work, she makes short, strange games and lo-fi electronic music.

AMARESH BHANGLE has left the fast-paced world of video games PR at Bastion behind for the even faster paced corporate landscape over at Amazon UK, where he’ll be working hard as a PR specialist.

TALAL MUSA has joined BGFG as their head of digital. Talal will oversee the growth and development of WePC, PC Guide and Videogamer.com. He was previously head of digital media at Gfinity, where he created and oversaw the Gfinity Digital Media Group, turning it into a network of multiple websites that reached millions of users every month. Talal has an extensive background in journalism and PR, and has worked with News UK, Edelman, The Daily Mail and M&C Saatchi.

SARA MACHADO is the newest senior recruiter at Sumo Group, and has a strong focus on diversity, inclusion and equality. She is known for creating the biggest recruitment survey in games; deep diving into candidates’ job hunting preferences and so that she can design what she considers to be the best hiring processes.

MATTHEW CHAPMAN is a new assistant game designer at Sumo Sheffield, and joins the studio after a short stint of work experience at the company. He also studies games design at Sheffield Hallam University, so we’re absolutely certain that he must be a very busy person.

LOUISE HEPPELL has also joined the team at Sumo Sheffield, as an HR administrator. She used to work in the care industry as an HR Administrator, and has an MSc in HRM. This is her first games industry role, and has told us that she is very excited about it.

AGNIESZKA PRZEPIORKOWSKA has become a senior learning and development advisor at Sumo Sheffield. Before joining the team at Sumo, she worked in translation, interpreting and language teaching jobs. She also used to proofread comic books, although we’re not told which ones.

KEVIN WAFER has joined the team at Sumo Sheffield as a principal technical artist. He’s worked in the industry for over 20 years, and has spent time at big industry companies like Activision, Electronic Arts, King and Sony Computer Entertainment Europe.

Wrapping up our list of new recruits at Sumo Sheffield is ASH LONG, their latest junior QA tester. He finds himself at Sumo after spending some time in the high pressure esports world. Ash used to work as head coach for Team Envy’s Overwatch League academy team and later as the head coach of Cloud 9’s Valorant team, before making the transition to full-time game development.

THEO CLARKE is the latest senior quality analyst at Red Kite Games, and comes to them after working at Soccer Manager Ltd and Traveler’s Tales. He’s worked on over a dozen games, across mobile, console and PC – and that’s not including the projects he’s told us he’s secretly working on at home.

MICHAEL HAZLE is the newest QA tester at Red Kite Games, coming to them from Universally Speaking, where he also worked in the QA department. Before that he spent some time freelancing as a journalist and content creator for The New Collection.

ELLIE BROWN is now a character artist at Sumo Nottingham. Before that she was a 3D Artist at Red Kite Games. Ellie also co-created Ocean Spark Studios, an academy that went to schools and ran workshops to give girls more of an insight into how games are made.

NINA KLOS has joined Sumo Leamington as a technical artist. She used to be an associate technical artist at DR Studios. Nina also has a BA (Hons) in game art, which she received from De Montfort University in Leicester.

ALEX FULLARTON is a junior programmer at Sumo Warrington. He is also a graduate from the MComp Computer Science for Games at Sheffield Hallam University. He’s from Darlington, which is the same place as MCV/DEVELOP’s staff writer Vince Pavey.

JOHN NEWBERRY is now a technical designer at The Chinese Room. He was previously at Bulkhead, where he worked to help bring The Turing Test to the Nintendo Switch and Google Stadia. He also worked on the video game Wardogs.

MICHAEL GENESIS ASIS has also become a senior environment artist at The Chinese Room. He used to work at Ubisoft Philippines, on AAA video game releases like Assassin’s Creed Origins, Assassin’s Creed 3 Remastered and Assassin’s Creed Valhalla.

JOE ROBINSON is the new communications director at Hooded Horse. Until walking into the stable he was the strategy editor for PCGamesN. With thirteen(ish) years under his belt across games media and PR, he is sure to be valuable to his new team.

JON TIBBLE has joined CI Games as vice president of global sales. He has worked in the industry for nearly 20 years, and was part of the team that relaunched the F1 series at Codemasters as director of sales, as well as numerous Activision Blizzard titles.

EMMA O’REILLY has
joined Snap Finger Click as a junior Unity engineer. She recently graduated from the University of Central Lancashire with first class honors in Computer Games Development and has a passion for 3D computer graphics. The studio’s upcoming Awkward 2 party game will be her main focus.

RUTH CARNEGIE has also joined Snap Finger Click as a junior Unity engineer. She graduated from the University of Abertay, specializing in Computer Games Technologies. Prior to this she achieved a first class degree at the University of Dundee in Applied Computing. Ruth’s passion for accessibility in games is a great fit for Snap Finger Click’s focus on multiplayer party games.

KALAM NEALE is the new head of education at British Esports. You might know him as the winner of the prestigious Pearson National Teaching Award, or as the key architect of the esports BTEC diploma. In his new role he intends to continue to help deliver a continued focus on esports as part of education.

ANDIE CHIVERS GOUDIE has joined Testronic as chief people officer. Andie has over 25 years of experience in HR, and joins the company following senior roles in the financial services sector and at the guitar manufacturing giant Fender.

Also at Testronic, ANN HURLEY has been promoted to senior vice president of sales and marketing. She has been at the studio for over seven years, and has played an important role in growing the company’s games business. As a Women in Games ambassador, Hurley has also been integral to Testronic’s EDI policies and initiatives.

CATHERINE BYGRAVE has moved from Gfinity to Humble Games, where she’s taken on the job of director of publishing strategy and growth. She is also a Women in Games Ambassador, and was on our shortlist for the MCV/DEVELOP Women in Games Awards in 2022.

MATT HANDRAHAN is now senior portfolio manager at Kepler. Before that, he was a game content analyst for global third-party relations at PlayStation. You may also remember him as the former editor-in-chief of GamesIndustry.biz, a job he held for nearly ten years.

SEAN MURPHY is now the studio outsource manager for Firaxis Games. Before joining the company he worked as an outsource manager at places like Aspyr Media and Armature Studio, so that makes sense. He’s been working in games in some form or other since 1985, so it’s safe to say that he likes them rather a lot.

CHRISTIAN WAIT has left his job as gaming guides and SEO writer at Social Chain, to become the newest gaming and tech SEO writer at GRV Media. He has a long history of being in the media, having once appeared on a live stand up Michael Barrymore VHS as a five year old. Christian also 3D prints and paints miniatures at @SaberMiniatures on Twitter.

Finally, ROGER COLLUM has joined Creative Assembly as vice president of the Total War franchise. He used to be head of studio development at EA Dice and has held several other positions in the industry over more than 15 years, including a stint as lead producer on Epic Games’ Fortnite.

How to improve iPhone 14 battery life

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If you’re seeing a faster battery drain than expected with iPhone 14 or 14 Pro you’re not alone. However, that doesn’t necessarily mean there’s a problem with your phone. Here’s a look at 7 tips and tricks to improve iPhone 14 battery life as well as why you might be seeing spikes in battery use.

The iPhone 14 lineup comes with what Apple says is roughly 1 hour longer battery for each model and the 14 and 14 Pro do feature larger mAh capacities (14 Pro Max capacity is ever so slightly less but battery life is up).

But people with the new iPhone 14 are sharing across Twitter and social media about having a bad experience with battery life so far. Let’s dig into what could be going on and how to improve battery iPhone 14 battery.

Table of contents

What causes battery use spikes?

  • Restoring a backup on your new iPhone
    • Things like downloading a large photo/video library are particularly draining
    • iPhone creates more heat when restoring and uses more battery
  • High background app activity
  • Using your new iPhone more than normal checking out new features, cameras, etc.
  • Combination of new hardware and software with early bugs (first iOS 16 releases)
    • Third-party apps and even some Apple apps may not be running optimally yet

There are many other factors at play, but these four are notable ones.

A couple of things to consider in the first few days of using your iPhone 14. Even after you’ve restored from a backup, it takes time to fully download your entire photo library, all your apps/data, etc. Your iPhone is working harder and is hotter than normal so it’s using more battery than normal.

In the Photos app, you can pause syncing/downloading with iCloud until evening. If it hasn’t done this automatically, open Apple’s Photos app > Library > All Photos > swipe to the bottom and tap “Pause.” Having that continue when you’re charging in the evening will help save battery.

In my experience, 17% of all battery use in the first four days for my iPhone 14 Pro was from the Photos app.

I’ve also seen much higher background app activity than normal across not just the Photos app but other Apple and third-party apps.

One bug I’ve seen is optimized battery charging with iPhone 14 Pro/iOS 16 has only powered my phone up to ~70% the last few nights. That, of course, makes a big difference if you’re not starting the day with a 100% charge.

You can turn that off by heading to Settings > Battery > Battery Health > Optimized Battery Charging – but keep in mind that may age your battery faster to keep it off permanently. Ideally, with a new iPhone, it will learn your schedule before long so it’s charged to 100% when you normally pull it off the charger.

Hopefully, some of these issues could be addressed with iOS 16.1 or other future updates. And after the first week, you might not be using your iPhone for quite as many hours each day and see your battery lasting longer.

How to improve iPhone 14 battery life

7 options instead of using a battery pack:

1. How are apps using battery?

Head to Settings > Battery to check out the details of your battery usage. “Last 24 Hours” is the default and shows which apps are using the most energy (including Home & Lock Screen and Siri).

  • Tapping the “Last X Days” toggle on the right-hand side gives you a broader look at what’s eating up your power.
  • Look for “Background Activity” under an app to learn if it’s been using energy behind the scenes.
  • Also, take a look at battery life suggestions just above battery usage (near the top). This will give you quick, actionable ways to reduce battery drain.
  • And, if you like to see the battery percentage on your iPhone – not just the icon – check out our guide:

2. Low Power Mode

Low Power Mode is a quick way to extend battery life. The feature works by suspending mail fetch, background app refresh, auto-downloads, and more with a single button. This isn’t an everyday-use feature, but it is handy.

You can turn on Low Power mode under Settings > Battery or ask Siri to do it. However, it’s useful to have quick access to Low Power Mode in Control Center. Navigate to Settings > Control Center > Customize Controls, then tap the + icon next to Low Power Mode if it’s not already there.

  • This is useful to stop all the background activity from apps when you’ve recently set up a new iPhone
Low Power mode

3. Auto-Lock, screen brightness, and always-on display

If you notice “Home & Lock Screen” on your battery usage is higher than you’d expect, it’s good to check those settings.

Auto-Lock at 30 seconds will help you preserve the most battery life. Especially with iPhone 14 Pro having an always-on display, 30 seconds can be worth it.

Navigate to Settings > Display & Brightness > Auto-Lock.

Lowering your screen brightness will also help with battery life, but this will come down to personal preference. You can do that in Control Center (swipe down from the top right corner) or Settings > Display & Brightness.

With iPhone 14 Pro HDR brightness now going up to 1600 nits and outdoor peak brightness going to 2000 nits, this is something to keep an eye on to help keep battery life in check.

Always-on display

We don’t have detailed data yet on how much battery the always-on display with the iPhone 14 Pro and Pro Max uses. Ideally, it won’t eat up as much as it goes down to a 1Hz refresh rate. But if you’re looking to eke out the most battery, turning it off could help a touch.

Head to Settings > Display and brightness > Always On at the bottom. Read about all the fine details in our full guide:

4. Hot and cold temps

Apple says the ambient temperature “comfort zone for iPhone is 32° to 95° F (0° to 35° C). Temps above 95° F (35° C) have the potential to “permanently damage battery capacity.”

Improve iPhone 14 battery life temps
  • Outside of keeping your iPhone from extreme heat, it’s good to remove your iPhone case if you notice it gets hot while charging or restoring from a backup.
  • Meanwhile, temperatures below 32° F (0° C) can temporarily reduce battery life. If you live in a climate with cold temps, keeping your iPhone closer to your body in an inside pocket can help extend battery life by keeping it warmer.

5. Background app refresh

Low Power Mode turns off background app refresh across the board, but you can customize which apps use this feature for a more convenient experience as well as improved battery life. Head to Settings > General > Background App Refresh.

You can also opt to only use a background app refresh on Wi-Fi in addition to Wi-Fi and Cellular or turn the feature off totally. However, most users will find leaving Wi-Fi and Cellular on while customizing which apps are used for a background app refresh to be the best fit.

Turning off Background App Refresh prevents apps that you’re not actively using from updating (until you open them again).

background refresh

6. Location services

Dialing in your location services settings is another way to extend battery life. (It can reduce cellular data use too). Head to Settings > Privacy & Security > Location Services to update the privileges for your apps.

  • Look out for any apps that ask to Always use your location and switch to While using, Ask Next Timeor Never.

7. Push and Fetch

If you choose not to use Low Power Mode, you can manually control Push and Fetch for your email/internet accounts.

Head to Settings > Mail > Accounts > Fetch New Data. One approach is to leave your primary account(s) as push to receive new mail asap, and turn less important accounts to fetch every hour or even set them to manual.

Wrap-up on how to improve iPhone 14 battery life

While it’s no fun to have a bad experience with battery life with a brand new iPhone, hopefully, these tips plus future updates from Apple and third-party apps will reduce battery drain.

Until then, keep an eye on what apps are eating up your battery the fastest, get Low Power mode in Control Center for quick access, and use as many of the settings discussed above as you can without making daily use a hassle.

If you find you’d rather not change many (or any) of the settings, another option is to just pick up a power bank or MagSafe battery pack.

More on iPhone 14 and iOS 16:

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