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LinkDaddy® Rolls Out Link Building Service for Small Businesses

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Backlinks & SEO Services You Can Trust!

LinkDaddy® - Backlinks & SEO Services

LinkDaddy®

LinkDaddy offers genuine link building services to small business owners, helping their websites compete more on search engine ranking.

This is an invaluable service to SEO teams and managers who know how to properly use Link Building services for boosting rankings.”

— Shriram Iyer

UNITED STATES, May 21, 2022 /EINPresswire.com/ — While businesses are realizing and acquiring more genuine links for their websites is important, it is also getting more difficult to acquire genuine high-relevancy backs. As an SEO strategy, broken link building and cold outreach are proving to be inefficient. As link building gets more saturated and with traditional backlinking methods providing little ROI, business owners need a trustworthy backlink building service that provides an SEO boost without the need to spend more dollars in advertising.

LinkDaddy provides one such comprehensive backlink service that includes – DoFollow backlinks, Business listing backlinks, Aggressive Tier 1 backlinks, and Google Stack backlinks.

46% of businesses allocate up to $10,000 or more from the marketing budget to link-building exercises and nearly 35% of businesses allocate more than $1000 per month for their link-building efforts. The reason is easy to understand – a site with a healthy and expanding backlink profile has every chance of finding the top position on the search engine results page. However, the costs can become overwhelming and unsustainable for many, especially the smaller businesses.

LinkDaddy provides a more affordable solution by helping sites develop a solid backlink profile in a rather shorter period without the need to manage any ad campaigns. For instance, the LinkDaddy Google Stack Backlinking service utilizes existing Google assets of a business, like Google Sites, Blogger, Docs, Sheets, Forms, and Slides. All these assets contain the company information and are made public, linking back to the main website. By using Google’s own assets and using them like authoritative domains, this LinkDaddy gig helps businesses quickly power up their linking profile, giving them a higher chance of getting indexed, crawled, and ranked better.

Building a backlink profile is not easy because link-building trends keep changing. While a few might provide fantastic results for a few weeks, some might not create any impact. More importantly, many link-building tools sold online don’t deliver at all in the longer run. This is why businesses need SEO experts who can keep up with how search engines interpret backlinks, differentiating the developing and mainstream trends from the upcoming, more disruptive trends.

The LinkDaddy team is up to date with the latest in backlink industry trends to boost link acquisition and retention and to ensure maximum impact. The idea is to deliver a domain authority score boost that is sustained over a period without any risk of getting spammed.

Despite the fresh and authoritative content being one of the most recommended ways to boost backlinking and bring organic traffic to a website, there are lots of efforts that don’t get rewarded right away. LinkDaddy business backlinks for citations present a solution to this problem. This gig ensures that a business website gets quick, effective, and genuine backlinks. For building this link strategy, the business owner does not need to spend indefinitely and there is no risk of being penalized by Google. This helps to control the cost, not requiring a business owner to continuously invest in creating and publishing content copies.

At all times, the LinkDaddy team checks that it lines up only top-quality backlinks, them for HTTPS security, strong organic traffic, and niche relevancy, staying away from sites that have a history of Google penalization or have had any run-ins with a link farm or a PBN.

This reinstates the fact that a business owner should not look at link building as a one-time exercise. This is an ongoing activity that helps to create, nourish, and multiply more backlinks, with an emphasis on maintaining high niche relevancy. The website gets more domain boost if the backlinking strategy ensures building DoFollow backlinks to the targeted website. While the speed at which this is done can vary, the consistency of the work matters. There are some digital agencies out there that provide bulk linking but very quickly, the backlinks are lost, and many turn out to be spammy, bringing down the overall domain authority.

LinkDaddy offers a premium, DoFollow SEO backlinking service that can provide a URL up to 300+ niche-authority backlinks with the assurance of more than 95% generic anchor text with DoFollow backlinks. The gig offers the freedom to link to the home page URL or any of the inner website pages, and even the product page of an eCommerce store.

A website must have good, engaging content but even more important is the regularity of refreshing the content, embedded with trending and evergreen keywords if the blogging is to bring about a boost in relevant backlinking. Google is attracted to high-quality organic content and the website blog presents an excellent way of publishing it. While small business owners realize the worth of blogs being the organic link magnet, they often don’t have the resources to maintain a blog. Think of local contractors like roofers and plumbers whose websites aren’t often updated and seldom refreshed with new content. This can be a major restriction for link-building efforts.

LinkDaddy offers help to such business owners with its Aggressive Tier 1 backlinking service for the big-money keywords. The gig has proven effective for service providers who can offer sufficient, if not excessive, branded URL anchor text. Using this gig, business websites get a kick in their placement in the SERPs. This is further boosted with the LinkDaddy PR service. Here, a team of PR specialists crafts a press release that is then published and shared across relevant news wires and content distribution networks that help to bring in genuine traffic, adding to a website’s niche-authority backlink profile.

A large portion of all clicks go to organic search whereas PPC ads deliver click volumes at a cost that continues to vary. While businesses continue to spend on Google Ads, few realize that the bigger gains are heavily biased towards organic search success. Yes, getting a website ranked is not a short-term or cheap affair but if done via an agency that can offer long-term affordability and consistency, the results can be highly rewarding. Getting even close to the first few results can bring about a massive boost in online traffic and genuine queries for service businesses that thrive on getting queries from the targeted demographic.

LinkDaddy provides the type of long-term collaboration that a business owner might seek to establish the website in the top tier of organic search results for a pool of keywords. The digital agency offers competitive packages that should be relevant for smaller businesses as well as medium-sized enterprises.

Many businesses thrive due to the local catchment where neighborhoods, communities, and nearby locations call upon them. Typical examples include dentists and plumbers. Such local businesses need more backlinks from genuine online directories that help their business details, like a phone number or email ID, to appear in local searches. Google’s consumer insight reports indicate that people making local searches tend to follow up with a high-intent query or might even visit the store. LinkDaddy’s backlinking strategy includes the use of local directories, blogs, newsrooms, and content distribution networks that create more visibility across local search results.

About LinkDaddy

Based out of Miami, Florida, LinkDaddy is a White Label SEO services provider. The company provides effective search engine optimization strategies & solutions to create more online engagement for a brand. Whether it is a neighborhood business that wants to feature higher up in the local search results or a startup pursuing a better ranking for its YouTube videos, LinkDaddy provides customized packages for all SEO requirements. The agency provides end-to-end backlinking services that include tier 1 backlinks, do-follow backlinks, Google Stack backlinks, local SEO backlinks, and mass page website backlinks. Business owners can ask for LinkDaddy’s domain power booster services with the confidence of legitimate practices, white hat SEO only. With access to one of the world’s largest niche blog networks, LinkDaddy can boost the relevance of web pages and other digital assets, helping business websites rank higher for different keywords and targeted locations. At all times, customers can opt for a no-obligation, zero-cost Free trial to understand the ethical link-building services and the different service packages.

Tony Peacock
LinkDaddy®
+1 305 399 9423
email us here

LinkDaddy® Rolls Out Backlink Ranking Service for Small Businesses

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The Four Things Keeping Digital Marketers Up At Night And How To Solve Them

Anyone in charge of digital ad spend knows all too well the inevitability of change, but there are some topics that are especially front of mind for digital leaders today.

The Drum and Oracle recently ran a survey with readers and found first-party data, brand safety, ad fraud and viewability to be major areas of concern. Some of those may not be new to you but why do marketers think those are essential to them right now?

While all the compliances matter, marketers have to think about growth. They have to protect their brand image and convey messages. The question is ‘how.’ With so much action all around, the job of a marketer has never been more difficult, and multi-layered. Even with all the changes happening in the landscape, maximizing every customer interaction remains the vital focus for marketers.

We spoke to industry leaders about these trends and how they are addressing them:

First party data, brand safety, ad fraud and viewability are emerging as some of the major areas of concern or areas of interest amongst marketers. How does that compare with your own priorities?

Michelle Hobbs, APAC lead for Platform GSK, Publicis Groupe: Have you been looking at our 2021 focus areas?! Yes, these are all areas of concern for our clients but they are not new this year, we have been working on these areas for the last few years so have comprehensive workstreams in place that we adjust on a frequent basis as we see the landscape evolve .

Rohan Kamra, regional digital marketing and sales enablement manager – Asia Pacific and Japan, Intel: All the above mentioned areas are of prime importance to me as well (in context of the my current job at Intel). First party data was always a priority primarily because of the nature of Intel’s business and value we put on building direct relationships that we own and manage rather than being dependent on rented ones. Because of a large percentage of our media spend going into all things digital – brand safety, ad fraud and viewability are key to ensure that our spends are not only efficient but also effective while keeping the brand safe.

Tripti Lochan, co-chief executive officer Asia at VMLY&R: Protecting our clients’ brands and making sure they remain authentic to their values ​​is not something new for us. We have always believed that to be successful and forge authentic and meaningful connections with consumers, brands need to have a purpose and a value that resonates. It’s our job to help them uncover this purpose and to communicate it in a way that creates a best-in-class experience. So, increased scrutiny on first-party data, brand safety, etc., is catching up to where we’ve always been.

Matt Bennathan, senior director, JAPAC, BR and LATAM, Oracle Advertising: It’s reassuring to see first-party data and brand safety at the top of the list by some margin. Brand safety has evolved from basic to sophisticated as advertisers and their agencies utilise more custom brand safety maps to identify suitable content using intelligent, adaptable classifications that understand the context for your brand or sector.

What is suitable for Microsoft is different than what is suitable for VW. Brand safety isn’t about dated keyword block lists and excluding adult content anymore – that comes as standard – but do not advertise to your first-party customer data in the wrong environment! And where your current customers are, you will find new customers.

How should marketers change their approach to ad targeting? Does context play a bigger part?

Publicis Groupe’s Hobbs: Context has always played an important role in advertising, there is a proven connection between context and how ads are processed which affects ad recall, brand perceptions and ultimately potential sales response. However, it’s only one part of the mix: targeting, reach and creative are also very important. The best ads have memorable creative served to an audience at scale within an environment a consumer is already engaged with.

Intel’s Kamra: I am personally a big fan of contextual targeting. The environment matters a lot in the context of what the end user is consuming and hence if approached with relevant messaging the chances of eliciting the desired action increases manifold Vs trying to use the approach of “following around” at the cheapest price.

VMLY&R’s Lochan: Data alone is irrelevant if you can’t look at it in the context of the consumer’s life. Brands need to think beyond just their own product or service, instead of looking at how they can put the consumer at the heart of what they do – which requires a good understanding of consumer behaviour, motivation and responses within a lifestyle context. Successful targeting then, is about understanding the ‘why’ as much as the ‘what,’ in order to connect with consumers on a deeper level, rather than just showing up in the right places. It’s the brands who can connect with consumers on cause and purpose in their targeting who will inevitably make the most impact and see the biggest returns.

How important are attention metrics becoming in measurement in a post-third-party cookie world?

Jonathan Beguely, senior client partner, Oracle Advertising: In 2012, the IAB and MRC introduced Guidelines for the conduct of Ad Verification, and since then, marketers, publishers, platforms, and agencies have been measuring the success of their digital media campaigns against three key metrics – valid, viewable and brand safe. Valid, viewable and brand safe are the baseline for measurement – ​​the foundation in which to build from. The next step is to look beyond verification toward attention.

Attention metrics provide marketers with more meaningful insight – they highlight which creatives, channels, platforms and targeting segments are driving impact. As an example, display advertising can be thought about in two attention groups – time spent, and engagement. For time spent, we look at metrics like active page dwell time, or exposure time, and for engagement we look at metrics like in-view time, interaction rate, and interaction time.

For a marketer, maximizing every customer interaction is vital, and when we think about that in the context of digital advertising, we think about maximizing the impact every impression can have on the intended audience. Verification gives an ad a chance to succeed, but that’s all it is, a chance. Marketers wanting to maximise their media budget and drive true advertising effectiveness need to be measuring their entire digital buy and need to be looking beyond verification toward attention.

Publicis Groupe’s Hobbs: We will be seeing Marketers place more importance on attention metrics over the next 12 months, before we are even in a post-third-party cookie world. There is some very interesting research in this space already which shows the difference in effectiveness of ads viewed on different platforms and within content that delivers a higher engagement. We are trialling the possibility of optimizing on attention and the increased effectiveness this can deliver in terms of increasing brand metrics (awareness, brand perceptions) for our clients.

Intel’s Kamra: Attention metrics will be a key in a third party cookie scenarios bringing focus on metrics like time in view, format, ad placement and importantly the role of creative which had diminished a little in the race to chase purely data points. While a general consensus exists on the value of attention metrics and their relation to business outcomes some gaps do exist in the measurement aspect of it relating to mobile advertising which will need technology and timely education to overcome.

VMLY&R’s LochanTo truly understand how well your content is performing, it’s important to not only look at how many times it’s been viewed, but also how long it was viewed for, and how consumers interacted with it. Was it shared, commented on, and how much real estate did it take up? These days, with so many touchpoints being added to the consumer journey, brands need to be cognisant of all these metrics in real-time so that they can understand the full picture, and make sure that the experience they are providing to customers is constantly being refined and improved for maximum impact and resonance with human need at the core.

To find out about more solutions to the industry’s top-of-mind topics, check out Oracle Advertising’s website and contact for more details. Recent industry topics are also available on the blog and a demo request is also available here.

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Enjoy Life Celebrates Three New Allergy-Friendly Cookie Varieties

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I have a surprise! Enjoy Life Foods has baked up three exciting new allergy-friendly cookie varieties: crunchy Birthday Cakesoft baked Monsterand soft baked Sunseed™ Butter Chocolate Chip. These sweet treats are certified gluten free, free from 14 allergens, and perfect for nearly every occasion. Yes, Enjoy Life Cookies are school-safe for lunchboxes, but they’re also ready to travel on vacations, rescue hunger on outings, and share at social gatherings…

Enjoy Life Celebrates Three New Allergy-Friendly Cookie Varieties This post is sponsored by Enjoy Life Foods, but we only share honest opinions and experiences. The photos are by Hannah Kaminsky.

New Enjoy Life Cookie Flavors are the Life of the Party

To put them to the test, I took each new variety of Enjoy Life Cookies to different get-togethers with a mix of people. The guests included dairy-free, gluten-free, nut-free vegan, and several no restriction friends. Below I’ve shared the taste profiles of these special cookies, followed by the social verdict from our unbiased and unsuspecting reviewers.

Birthday Cake (Crunchy)

The pastry chefs at Enjoy Life figured out how to naturally bake the essence of warm vanilla birthday cake (complete with sprinkles) into a cookie. They’re colorful, perfectly crisp, and ready to party!

Group Review: I served these at a 50th birthday party with guests of all ages (from 5 to 75). I knew there would be some special diet needs and wanted to ensure there was dessert for all. And I must say, EVERYONE loved these cookies. The traditional cupcakes were barely touched, but the Enjoy Life Birthday Cake Cookies were devoured. I actually had to set some aside for the gluten-free guests (and for me) since they were disappearing so quickly. Several people asked me where they could buy them, and one person suggested using them for dairy-free ice cream cookie sandwiches – yum!

New Enjoy Life Cookies!  Birthday Cake, Monster, Sunseed Butter Chocolate Chip, and seasonal Strawberry Lemonade - all dairy-free, egg-free, gluten-free, nut-free, peanut-free, soy-free, sesame-free, and vegan!

Monster (Soft Baked)

These mighty bites are stocked with colorful chocolate candy gems, chocolate chips, oats, sunflower seed spread, and vanilla. The taste is scary good, but don’t worry, they’re still safe from 14 allergens.

Group Review: These were the sweet ending at a casual gathering with about ten people, including four of us with special diet needs. Everyone loved the perfectly sweet flavor, the slightly hearty texture, and the intriguing add-ins. We all agreed, they were dessert-worthy and positively addictive, but also wholesome enough for snacks. In fact, I’m ordering some more boxes of Enjoy Life Monster Cookies to pack along for hiking rewards.

New Enjoy Life Cookies!  Birthday Cake, Monster, Sunseed Butter Chocolate Chip, and seasonal Strawberry Lemonade - all dairy-free, egg-free, gluten-free, nut-free, peanut-free, soy-free, sesame-free, and vegan!

Sunseed Butter Chocolate Chip (Soft Baked)

This is Enjoy Life’s nuttiest free-from cookie yet. The soft and chewy texture is amplified with smooth, rich sunflower seed spread, and generously dotted with their signature mini chocolate chips. It’s a delicious classic remade without 14 allergens, like all Enjoy Life products, including dairy, eggs, gluten, peanuts, tree nuts, sesame, or soy.

Group Review: I put a plate of these out with an assortment of eats after a beach day. Not surprisingly, they were the first thing finished! Our small crew thought these were perfect for lunchboxes, school socials, and day trips. We all liked the tender texture and the gently sweet flavor that wasn’t the least bit sugary. The overall consensus for Enjoy Life Sunseed Butter Chocolate Chip Cookies was “wonderfully comforting” and “insanely snackable.”

New Enjoy Life Cookies!  Birthday Cake, Monster, Sunseed Butter Chocolate Chip, and seasonal Strawberry Lemonade - all dairy-free, egg-free, gluten-free, nut-free, peanut-free, soy-free, sesame-free, and vegan!

Bonus: Strawberry Lemonade Cookies (Crunchy)

There is one more new flavor, but this one is seasonal! These vibrant cookies are an ode to America’s favorite summer beverage. They have a snappy bite and zesty lemon taste complemented by the essence of sweet strawberries.

Availability: These sweet-tart treats are available online for spring and into summer, but only while supplies last. So be sure to order your boxes now.

New Enjoy Life Cookies!  Birthday Cake, Monster, Sunseed Butter Chocolate Chip, and seasonal Strawberry Lemonade - all dairy-free, egg-free, gluten-free, nut-free, peanut-free, soy-free, sesame-free, and vegan!

Where to Buy Enjoy Life Cookies

You can order all Enjoy Life Cookie varieties direct from their website right now! They ship direct to customers throughout the United States. Order them here ⇒ enjoylifefoods.com/cookies

The new flavors are also available at Wegman’s and Albertson’s Safeway stores, and will continue to pop up in other stores in the coming months. See their store locator here ⇒ enjoylifefoods.com/store-locator

I Love My Teaching Job, But It Doesn’t Pay Me Enough

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Photo-Illustration: by The Cut; Photos: Getty Images

I’m a high-school history teacher, and I really enjoy it. It’s what I’ve always wanted to do, and I love my kids and my colleagues. I work at a small private school, which comes with some drama and drawbacks, but overall I’m happy here. The problem is that the pay sucks. Most of my fellow teachers seem to have family money or a wealthier spouse, but I have neither and can barely make ends meet. My salary is about $60K a year, which doesn’t take you very far in Brooklyn, especially with student loans. (Mine are on hold right now, but I’m dreading the day payments resume.)

My co-workers act like this is just part of the work we do, like we’ve taken a vow of poverty to be teachers or something. And I used to buy into that or not care as much. But now that I’m in my 30s, it’s starting to bother me that I have almost no savings. It took the pandemic (and the student-loan freeze) to enable me to pay off my credit-card debt.

I don’t want to abandon my career. I’m good at it, and I’ve put over a decade of my life into it. Plus what else am I even qualified to do? But I’m starting to realize that this just isn’t sustainable. I’ve pretty much given up on the idea of ​​ever owning a home. And the irony is, if I ever had kids, I could send them to the fancy school where I work for free — but I don’t know if I could afford to support them otherwise. Sure, I have nice benefits, and I put money away for retirement, but I work with some teachers in their 70s who literally can’t afford to stop working. How can I avoid that fate?

First of all, you deserve to get paid more. It’s absurd that we ask so much of teachers and don’t compensate them better. This is a major systemic problem, and I wish I could change it. But I can’t, so we’ll need to step back and consider your options.

I’m glad you love what you do, and I’m sure you’re brilliant at it. I’m also glad you’re taking a moment to reevaluate whether this career choice isn’t lining up with what you need or want in the future (the income to live comfortably, potentially support a family, and retire eventually).

To start, you need to gather information. If you want to remain a teacher, you probably have to do at least one of the following: find a school that pays you better, move to an area that costs less, or pick up some side gigs to supplement your income. Obviously, these paths are not simple or easy. But neither is squeaking by without enough money to do the things you want.

Speaking of which, what do you want? I’m not asking you to map out a rigid life plan to the letter, but it’s wise to think about what financial security actually means to you. These are just some examples: Maybe it would look like traveling to see family a few times a year, renting a one-bedroom apartment on your own, and being able to go out to dinner once a week without stressing about your bank balance and retirement account. Or it could look like saving and investing more aggressively so you can afford a down payment on a home in five to ten years. Or you might want to take one major, amazing international trip every summer and spend $5 on fancy coffee every day. It’s up to you! Remember, what you want doesn’t have to line up with “traditional” ideas about financial success (house, children, etc.). You get to skimp on the stuff you don’t care about and spend more on the things you love.

Once you’ve gotten more clarity on what you hope to afford, you can look at your current income and see what’s realistic. This might be sobering. But it can also push you to make some big overhauls if necessary.

“When you get to the realization that your situation is unsustainable, that’s often a good time to make a drastic change,” says Rashad Muhammad, a school principal in Fort Worth, Texas, who runs a YouTube channel about building wealth on an educator’s salary . He and his wife, a prekindergarten teacher, began their careers in Florida and quickly realized their income wouldn’t support the kind of family life they wanted (three kids, healthy retirement savings, and enough money to go on vacations). So they started researching which areas paid educators the most and offered lower costs of living. “At the time, most of the major cities in Texas were the best fit for us,” he says. They settled on Fort Worth.

Obviously, Texas is not for everyone. And Muhammad says there were downsides to this decision — he and his wiife didn’t know anyone there at first, for starters. Moving also may not be realistic for you, and there are a zillion great reasons to stay in Brooklyn. (I would know: I live here, too.) But broadening your horizons might turn up some options you haven’t previously considered. “There are a number of major cities where you could be making $65,000 or $70,000 and probably cut your expenses in half,” says Muhammad. He recommends doing some research on where your salary could go the furthest. “It’s a simple math equation,” he adds. “And right now, you have a great advantage in that you don’t have kids, so you’re relatively untethered.”

Regarding your student loans, I recommend that you look into the Public Service Loan Forgiveness Program. Many private-school teachers qualify, provided their employer is a nonprofit organization and provides elementary and/or secondary education according to state law. The Biden administration recently made it easier to enroll and, for a limited time, is granting credits to people whose payments did not previously count. If you’re able to take advantage of this, it’s almost definitely worth continuing your teaching career until your debt is forgiven.

It’s also worth looking at potential career transitions. I spoke to a teacher in Colorado who reached her salary cap (about $60,000) and realized she’d be better off working in an adjacent field. Now she’s taking classes to get a job working in education technology. The coursework does cost money — about $15,000 — but the salary bump will be significantly more than that.

I’m sure you’ve considered supplementing your salary through tutoring, working at summer programs, and so on. Muhammad pointed out that those side gigs can add up to an additional $10,000 to $15,000 a year or possibly even more. As I’m sure you know, public schools tend to pay better than private ones. I understand you may not want to leave the school where you work now, but you might be able to pick up some relatively lucrative summer jobs in the public system.

My point is you do have choices, and you aren’t trapped. I also think your conundrum is more common than you may realize. As you contemplate your next steps, your best resource could be other teachers, particularly those outside of your school — there are many websites, online groups, and even podcasts for educators who are trying to make their careers work better for them. Don’t be shy about networking and asking people how they make ends meet. You’ll probably be able to pass along the favor to another teacher someday.

Chris Brown and Rihanna’s Dating History and Relationship Timeline

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Back in the day, Rihanna and Chris Brown were one of the most popular couples in Hollywood. Keep scrolling to catch deep insights about their relationship from their first meeting to the tragic end of their whirlwind romance.

When did Rihanna meet Chris Brown?

The Love The Way You Lie singer met Chris for the first time in the year 2005. These two crossed paths at Met Circa in 2005 however they did not start dating until 2007. At the time, they were just teenagers who made it big in the world of music at a young age.

During the same year, Queen RiRi and Chris were also snapped backstage at the Z-100 Jingle Ball held at Madison Square Garden in December. From that day on, the paths of these two singers kept meeting at one point or another.

Rihanna and Chris Brown worked together on a song in 2008

The romance rumors of the Fenty Beauty founder and the Loyal rapper began going around in circles in 2008. Their on-stage chemistry was so hot that it could put the stage on fire.

Soon afterward, Rihanna dropped a song named Umbrella which was the lead single on her album Good Girl Gone Bad, and the track earned her a Grammy Award. She and Chris collaborated on the remix of the song.

Chris recorded an ‘answer song’ titled Cinderella in which he replaced some of the lyrics, set to the same beat. It was the pair’s first collab ever and he even joined her on the stage during her tour in Asia to perform the remixed version live. It was confirmed in 2008 that the two of them were dating.

As per the reports, the pair decided to arrive at the Grammys 2008 separately even though they were dating then and they were photographed getting cozy at the event. Two days after, Chris sang on the occasion of Rihanna’s 21st birthday and it is believed he ended the song with a kiss. Everything was going well for these lovebirds but things turned upside down in 2009.

Chris Brown got arrested for assaulting Rihanna in 2009

The Look At Me Now singer and Rihanna were supposed to perform together at the Grammys 2009 but on the day of the award show, it was announced that the pair will not be taking over the stage. It was revealed that Chris brutally beat up Rihanna the night before the award ceremony.

Chris busted Rihanna’s lip and left her with black eyes and many bruises. When the pictures of Rihanna surfaced on the internet, our hearts literally sank after taking a look at them. In the photos, the Needed Me singer could be seen in a hospital bed with a bruised and bloody face post the verbal and physical fights between the couple.

Soon afterward, Chris was arrested by the police authorities and he was charged with felony battery. Their case started in court in the midst of 2009 and at the end of the case, Chris was found guilty of the charges and was charged to five years of probation along with community service and domestic violence counseling.

On the other hand, Rihanna also filed for a restraining order, as per which Chris was not allowed to stay within 50 yards of her. Their relationship hit the rock bottom and it shocked people all over the world.

What did Rihanna have to say about the whole incident?

In 2009, the Diamonds singer talked about her relationship with Chris and the entire incident that took place in an interview with Vanity Fair. At the time, she said, “Well, I just never understood that, like how the victim gets punished over and over. It’s in the past, and I don’t want to say, ‘Get over it,’ because it’s a very serious thing that is still relevant; It’s still real.”

Rihanna further added, “A lot of women, a lot of young girls, are still going through it. A lot of young boys too. It’s not a subject to sweep under the rug, so I can’t just dismiss it like it wasn’t anything, or I don’t take it seriously.”

The rock star went on to say, “But, for me, and anyone who’s been a victim of domestic abuse, nobody wants to even remember it. Nobody even wants to admit it. So to talk about it and say it once, much less 200 times, is like… I have to be punished for it? It didn’t sit well with me.”

In a 2009 interview, the Barbadian singer said, “I was that girl who felt that, as much pain as this relationship is, maybe some people are built stronger than others. Maybe I’m one of those people built to handle [things] like this.”

Queen RiRi added, “Maybe I’m the person who’s almost the guardian angel to this person, to be there when they’re not strong enough, when they’re not understanding the world, when they just need someone to encourage them in a positive way and say the right thing.”

The We Found Love singer continued, “You want the best for them, but if you remind them of their failures, or if you remind them of bad moments in their life, or even if you say I’m willing to put up with something, they think less of you – because they know you don’t deserve what they’re going to give.”

Rihanna concluded by saying, “And if you put up with it, maybe you are agreeing that you [deserve] this, and that’s when I finally had to say, ‘Uh-oh, I was stupid thinking I was built for this.’ Sometimes you just have to walk away.”

Chris Brown’s side of the story

In his June 2017 documentary titled Welcome To My Life, Chris put some light on what led to their 2009 fight. He said, “My trust was totally lost with her, she hated me after that. I tried everything, she didn’t care. She just didn’t trust me after that.”

He further added, “From there, it just went downhill because there were too many verbal fights, physical fights as well. Mutual sides. It is the first time I get to say anything. We would fight each other. She would hit me, I would hit her and it never was OK.”

Rihanna and Chris reconciled their romance in 2012

Chris was killed to a total of five years of probation after the physical assault case got legal and got everyone’s attention too. But things took a turn in the year 2012 when the couple got back together and Rihanna thought that she could change him and make him a better person.

This came like a big shock to all the Rihanna fans. In 2012, during an episode of Oprah’s SuperSoul Conversations, the Dancing in the Dark singer discussed her and Chris’ relationship with host Oprah Winfrey.

At the time, Rihanna confessed and she said that Chris was her true love and said that she considers him the “love of [her] life.” She further added, “We’ve built a trust again, and that’s it. We love each other and we probably always will. That’s not anything that we’re going to try to change. That’s not something you can shut off if you’ve ever been in love.”

The Bitch Better Have My Money singer also revealed that she had taken back the restraining order and she had forgiven him. She continued, “It took me a long time. I was angry for a long time. I was resentful, I held a grudge. I was dark. I was angry. It was coming out in my music and my clothes and my attitude. I didn’t like that feeling. It was heavy.”

When the couple got back together, they were spotted out and about in public together sitting courtside at basketball games and getting cozy on vacations together.

Rihanna and Chris broke up in 2013

The pair split up in 2013. Chris confirmed the news of their breakup and he spoke about the same during a radio interview with the Kyle and Jackie Show in Australia. He said, “I mean, at the end of the day, shawty doing her own thang, she on the road. It’s always gonna be love. I’m a grown man, just gotta fast forward.”

Chris recently congratulated Rihanna on her baby boy

Not long ago, Chris Brown took to his Instagram to wish his ex-girlfriend Rihanna congratulations as she welcomed her first baby with A$AP Rocky. He offered his congrats to Rihanna on Thursday post the news came out that she had given birth.

The R&B singer simply wrote, “Congratulations” on his Instagram Story. Even though he didn’t tag Rihanna in the story. He just dropped an emoji of a pregnant woman, a heart, and prayer hands.

We are happy to see that Rihanna has moved on in her life and she has finally found someone who loves her the way she deserves to be loved. She recently welcomed her first child, a son with her beau A$AP Rocky. Sending lots of love and happiness to their little bundle of joy. Don’t forget to stay tuned with us for more updates from the world of showbiz.

Clovis Unified Updates Dress Code

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Wednesday, Jan. 12, The Clovis Unified School District Board made official changes to the dress code during their first public meeting of 2022.

The dress code for CUSD has been a continuous concern for both parents and students throughout the years.

In a survey that presented to parents, students, and staff on Nov. 18th, a majority of participations elected the dress code needed to be changed.

The biggest issues in those surveys came in the form of leggings, shorts, and frayed/ripped clothing.

Another concern came in the form of code enforcement. Students saw inconsistent enforcement of the dress code.

Female students expressed concerns about the code not sending the message they want it to send. They feel they’re being sexualized and being singled out for what they wear.

Clovis North student Regan Larson told a story about how the dress code didn’t protect her from being sexualized.

“My freshman year, I was sexualized multiple times and then assaulted by a boy in my first period class,” Larson said. “I was completely compliant with the dress code. Students Services’s way of protecting me was giving the boy a one day suspension and telling him to stay away from me. Unfortunately, I had to stand next to him in class every day following the incident.”

Larson also stated that the dress code teaches her that the way she dresses makes her at fault for how boys might stare, comment, or touch her without her consent.

Superintendent Eimear O’Brien spoke to the board after public comments and stated how they would handle the issue of code enforcement.

In preparation for the meeting, a pamphlet was given to each board member titled “What to Expect with Dress Code Enforcement”. The pamphlet explained what to expect a student should be in violation of dress code without students feeling singled out or violated.

Once published the pamphlet will be accessible on all CUSD websites for anyone who wishes to read it.

O’Brien also stated that staff are being trained based upon what is stated within the pamphlet.

In regards to the dress code itself, a motion was made unanimously to approve the new draft that was previously presented to the public on their website.

Board Member Yolanda Moore expressed her appreciation to the community and hopes the new code will receive good feedback.

“I appreciate the young people advocating, I appreciate all of the input from the community, but also all the work that administration put in just getting us all the comments and the raw data and just seeing what the community wanted,” Moore said. “I hope this is something that people will be happy with because, just from what I’ve seen I think the changes we’re suggesting do a good job of, not only upholding the role of our dress code, but also allowing them to express themselves and keep up with the fashion trends.”

Board Member Susan K. Hatmaker also expressed thanks to everyone who participated in the meetings and pushed for change in the dress code “all during a pandemic.”

Study suggests obesity paradox for those over 80 due to non-cardiovascular disease mortality

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Credit: Unsplash/CC0 Public Domain

A team of researchers affiliated with multiple institutions in China and the US has found that the obesity paradox for those over 80 is driven mostly by non-cardiovascular disease mortality rates. In their paper published in the journal Nature Aging, the group describes their study of 20 years’ worth of health-related data for several thousand older people living in China and what they learned from it. Jean Woo, with the Chinese University of Hong Kong, has published a News & Views piece outlining the history behind the use of the body mass index (BMI) and the work done by the researchers in this new effort, in the same journal issue.

For many years, people around the world have been told that in order to live a healthy life, they need to keep their BMI below 25. But as Woo notes, the BMI was created using data from younger people. In recent years, an obesity paradox has emerged for people older than 65—those with a higher-than-recommended BMI live longer than those who have adhered to the standard. In this new effort, the researchers found evidence that suggests this paradox is driven mostly decreased by non-cardiovascular mortality rates.

The work by the team involved analyzing health-related data collected from 27,026 older people (mean age approximately 93 years old) living in China over the years 1998 to 2018. Included in that data was the BMI of each individual as they grew older, the age at which they died and the cause.

The researchers found evidence of the obesity paradox—those people over 80 who had a BMI in the overweight to slightly obese range lived the longest. But they also found that it was mostly due to non-cardiovascular mortality rates. Such people tended to live longer if they had a respiratory disease or even cancer. Even those who were clearly obese tended to live longer than those who were under the BMI guidelines. The researchers also found a very slight increase in longevity for those with cardiovascular disease, but suggest it was negligible.


‘Obesity paradox’ debunked: Obese people really don’t live longer than normal weight people with heart disease


More information:
Yuebin Lv et al, The obesity paradox is mostly driven by decreased noncardiovascular disease mortality in the oldest old in China: a 20-year prospective cohort study, Nature Aging (2022). DOI: 10.1038/s43587-022-00201-3

Jean Woo, What is an optimal BMI after eighty?, Nature Aging (2022). DOI: 10.1038/s43587-022-00212-0

© 2022 Science X Network

Citation: Study suggests obesity paradox for those over 80 due to non-cardiovascular disease mortality (2022, April 26) retrieved 21 May 2022 from https://medicalxpress.com/news/2022-04-obesity-paradox-due-non-cardiovascular -disease.html

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Quitting Smoking Even After Lung Cancer Diagnosis Worth Doing

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Patients who quit smoking at or around the time of a lung cancer diagnosis live longer than those who continue to smoke, concludes a new meta-analysis.

“Smokers who quit smoking at or around lung cancer diagnosis have a 29% improvement in their overall survival compared with those who continue smoking,” Saverio Caini, MD, PhD, Institute for Cancer Research, Prevention and Clinical Network, Florence, Italy, and class observer.

“Treating physicians should educate lung cancer patients about the benefits of quitting smoking even after diagnosis and provide them with the necessary smoking cessation support,” they stress.

The study was published in the May issue of the Journal of Thoracic Oncology.

“It is time to stop ignoring the obvious and to fully integrate smoking cessation into quality cancer care,” experts comment in an accompanying editorial.

Meta-Analysis of 21 Studies

A total of 21 studies published between 1980 and 2019 were included in the systematic review and meta-analysis, with around 15,000 patients overall, including 5315 patients with a diagnosis of nonsmall-cell lung cancer (NSCLC), 5133 patients with small-cell lung cancer (SCLC), and 4490 patients with lung cancer of both or unspecified subtypes.

“In most studies, quitters were those who stopped smoking at diagnosis or at some point thereafter,” the investigators explain.

Quitting smoking at or around the time of diagnosis was significantly associated with a 23% improvement in overall survival for patients with NSCLC, regardless of the histologic subtype (P = .812) and a 25% improvement in overall survival for patients with SCLC compared with those who continued to smoke, the authors report.

Furthermore, quitting smoking at or around the time of diagnosis seemed to be beneficial for patient prognosis even when evaluating endpoints other than overall survival, the authors continue.

For example, among the patients with NSCLC, quitters experienced a 30% longer progression-free survival in at least one study, while another study found that quitters had a 46% longer disease-free interval.

Several other studies support the observation that patients with SCLC who quit smoking enjoy significantly longer disease-free survival than nonquitters.

Another study found that locoregional control of lung cancer was again 46% longer among patients who quit smoking than among those who continued to smoke, although these positive benefits were not consistently seen in all studies.

As the authors observe, smoking promotes tumor growth, progression, and dissemination. It also decreases the efficacy of — and tolerance to — radiation and systemic therapy and increases the risk of postoperative complications and secondary primary cancers.

On the other hand, patients who quit smoking at or around the time of cancer diagnosis may differ from nonquitters in terms of demographics or tumor characteristics that could also affect survival, the authors comment.

Quitters may also be more likely to receive resection with curative intent and patients with earlier-stage lung cancer might be more motivated to quit smoking in order to enhance their likelihood of recovery. “Lung cancer remains a disease with a generally poor prognosis, despite the advances that have occurred over the past decade, including the introduction of immune checkpoint inhibitors (alone or in combination) effective for both NSCLC and SCLC,” Caini and colleagues observe.

They also observe that lung cancer screening could serve as a “teachable moment” to help patients quit smoking by integrating a cessation program into screening activities, which would benefit not only those testing negative on screening but also those eventually diagnosed with lung cancer.

Declining Incidence/Mortality

Commenting on the findings in an editorial, William Evans, MD, McMaster University, Hamilton, Ontario, Canada, and colleagues comment that “smoking is the common theme across the continuum of cancer risk diagnosis and treatment.”

“Continued smoking after a cancer diagnosis increases the risk of overall and cancer-related by a median of 50% to 60% across disease sites and treatments,” they warn.

In contrast, results from the current study suggest that the survival gains achieved by quitting smoking at or after a cancer diagnosis could rival those achieved with modern therapeutic approaches.

“It is important to note that the benefits of quitting smoking were obtained in combination with standard lung cancer treatment and that smoking cessation support did not compromise the therapeutic benefits achieved with evidence-based NSCLC treatment,” Evans and colleagues point out.

Despite this, large surveys of oncologists have revealed that most of them do not regularly help patients with smoking cessation, they observe.

Efforts both in Canada and the United States are underway to increase access to smoking cessation in cancer care, including the Just ASK initiative being disseminated at US cancer centers this year.

In the meantime, the editorialists emphasize that patients clearly do worse if they keep smoking.

“Patients need to clearly understand that smoking negatively affects their cancer treatment and that smoking cessation could improve their outcomes. This discussion needs to occur as soon as patients begin their diagnostic workup or treatment,” the editorialists comment.

“When smoking cessation could improve survival by 20% to 35%, as suggested by Caini et al [in this meta-analysis]should not every patient have the opportunity to achieve the best possible outcomes?” they continue. “Shouldn’t every care provider want that for their patients?”

The study was supported by the Italian Ministry of Health. The authors and editorialists have reported no relevant financial relationships.

J Thorac Oncol. 2022;17:596-598, 623-636. Full text, Editorial

For more from Medscape Oncology, join us on Twitter and Facebook.

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The Best Eating Behaviors to Follow for Finally Losing Weight, Says Expert — Eat This Not That

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Many folks try to lose weight and it is no easy feat—those who do shed off pounds tend to regain it back. Oftentimes people intend to change their lifestyle habits only to break these healthy habits soon after. So what does it take to keep those habits in your life?

We spoke to a behavior change expert to find out why people have such a tough time losing weight and what are the best behaviors to follow that can help enable successful weight loss.

“For nearly all of us, there is often a gap between what we intend to do and what we end up doing,” says Allison Grupski, Ph.D. and Vice President of Behavior Change Strategies & Coaching at Weight Watchers. “This happens because we’re human—which means that pretty predictable things get in our way. But there are ways to bridge that intention-action gap, especially for those looking to lose weight or get healthier.”

Here are five behaviors that can help make your healthy goals doable. Then, for more on long-term weight loss tips, take a look at This Diet and Exercise Combo Is the Key to Long-Term Weight Loss, New Study Says.

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“We often think that to lose weight, we must entirely change our lives,” says Grupski. “We imagine some version of our future self who is doing all of the ‘right things’ and living our best life. And for most of us, the distance between today-us and that imagined best-self-us is not insignificant.”

Behavioral theories suggest that the less attainable a goal seems, the less likely we are going to take action. Instead of envisioning a complete transformation, Grupski says to set goals that have a 95% chance of you repeating and repeating. In order to do that, get really specific about what you will do and when; focus the goal on something you will get some enjoyment from doing; and make sure your approach is one that genuinely fits into your life as it is today.

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Grupski explains that we tend to think about what we will or won’t eat or whether we’ll start jogging again or try a new workout. But we often stop short of really figuring out “how” to make it happen.

“This is why it’s important, when we’re deciding on what we want to do differently to focus even more energy on exactly how we’ll make it happen,” she says. “We should ask ourselves questions like: what exactly am I going to do? When will I do it? What might get in the way and how can I plan for that?”

making a plan
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“We often have an all-or-nothing thinking style when it comes to making healthy changes,” Grupski says. “So when we miss the mark of what we planned to do, we think of it as a ‘mess up’ or as evidence that we ‘ruined’ the good stuff we already did.”

This way of thinking makes a big impact on what we do. For example, when we think “well, I already ate 2 cookies … might as well finish the sleeve.” This is where noticing our thinking patterns, gently challenging them, looking at the big picture, and practicing self-compassion come in.

weight loss progress
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Many folks like to see those numbers drop on the scale, especially when the results are quick. When weight loss happen slowly, plateaus, or even reverses people tend to get discouraged and don’t want to continue on their weight loss journey—even though this almost always tends to along the way.

“This is where keeping the big picture of health in mind and focusing on off-the-scale progress—like improved energy and mobility—come in,” Grupski explains. “And some research even suggests that focusing on process more than the outcomes can help you stay on track.”

healthy eating behaviors
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When it comes to eating behaviors, here are several behavioral strategies that Grupski suggests to help support your weight loss journey.

  • Practice self-compassion: Most folks fall off the wagon or “mess up” and that is 100% normal and inevitable. Recognize that you’re human, talk kindly to yourself, and move forward.
  • Track what you eat: Research shows that tracking what you eat is a powerful behavioral strategy for weight loss and maintenance. You don’t have to count every morsel or figure out how many calories you just ate in a meal. It’s a simple form of self-monitoring and developing awareness. Tracking what you eat gives you a chance to start noticing patterns and can be very empowering. Research from the WW Success Registry suggests that food tracking can help members successfully lose weight and keep it off says Grupski. “Specifically, 74.4% of WW Success Registry members (those who lost at least 20 pounds on WW and kept it off for at least a year) reported tracking what they ate “most of the time” or “always” compared to 7.4% of the weight stable control group.”
  • Plan ahead: You’re much more likely to eat whatever is in reach when you get hungry. That’s when planning comes in handy. Having healthy foods inclusive of whole grains, fruits, vegetables, lean protein, healthy fats, low and nonfat dairy available make them more likely to be included in your meals and snacks. Even better if you can pre-plan your meals and snacks so you don’t have to think twice when it’s mealtime.

READ MORE: These Behaviors Increase Your Dementia Risk, According to Doctors

Toby Amidor, MS, RD, CDN

Toby Amidor is an award winning dietitian and Wall Street Journal best-selling cookbook author who believes healthy and wholesome can also be appetizing and delicious. Read more

Trends That Will Transform Asthma Care in 2022

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In 2022 and beyond, the care of patients with asthma will likely be transformed by novel monoclonal antibodies targeting cytokines, new asthma guidelines emphasizing precision medicine, and real-world evidence on the efficacy of newer asthma drugs. These were among the predictions made by Jon Romeo, DO, chair of the American College of Allergy, Asthma and Immunology Asthma Committee. In an interview with Pulmonology AdvisorDr Romeo, an allergy and immunology specialist in Raleigh, North Carolina, offered his views on what’s ahead in 2022 as well as the most important developments in asthma care during the past year.

In 2021, research on monoclonal antibodies took center stage, said Dr Romeo. Especially notable were several landmark studies on the monoclonal antibodies tezepelumab and astegolimab, both of which showed impressive efficacy in reducing asthma exacerbation rates.1,2 A few weeks before the end of 2021 ended, this research finally bore fruit when Tezspire, a tezepelumab-based pharmacologic agent (tezepelumab-ekko), received Food and Drug Administration approval.3-5

“I think those 2 drugs [tezepelumab and astegolimab] are fascinating and are going to be really helpful as being additional treatment options for patients with severe asthma,” said Dr Romeo. “We have a number of biologics already approved for severe, persistent asthma, all monoclonal antibodies directed at asthma, all of them directed at T2 asthma,” he noted. “But the drugs we currently have on the market really only treat certain subsets of people with severe asthma, either those with high eosinophil levels or those that have an allergic phenotype to their asthma.” This means that the asthma treatments that have been available thus far “don’t really work that well” for a significant subset of people with asthma, he explained.


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“The most interesting thing about these 2 [new] drugs,” he continued, “is that they are focused on a different aspect, the cytokines, released from the respiratory epithelium, and they did show effectiveness in all comers with severe asthma regardless of their T2 status.”

Tezepelumab is a first-in-class human monoclonal antibody that works by blocking thymic stromal lymphopoietin, an epithelial cytokine involved in the initiation and persistence of airway inflammation.3-5 Astegolimab, a human immunoglobin G2 monoclonal antibody, selectively inhibits the interleukin-33 receptor, ST2, and in doing so may target pathogenic pathways in a wider spectrum of asthmatics.2

The FDA’s recent approval of Tezspire should change asthma care in the year ahead, he stressed. Tezspire, a monoclonal antibody used as an add-on maintenance treatment for patients 12 years of age and older with severe asthma, is administered subcutaneously to patients by a health care provider once every 4 weeks.3-5 “I think it’s going to be a real game-changer for those people who have not responded to the agents that we’ve had on the market the last couple of years.”

FDA approval of Tezspire followed the phase 3 NAVIGATOR trial (ClinicalTrials.gov Identifier: NCT03347279), the results of which were reported this spring in the New England Journal of Medicine.1 In that trial, investigators found that participants receiving tezepelumab had approximately 50 percent fewer asthma exacerbations relative to placebo. The trial included 1059 participants who were 12 to 80 years old (528 who received tezepelumab and 531 who received placebo) with severe uncontrolled asthma and a wide range of blood eosinophil counts. Participants received tezepelumab or placebo subcutaneously every 4 weeks for 52 weeks while they continued their previously prescribed inhaled glucocorticoids and additional controller medications. The trial found that individuals receiving tezepelumab showed improvement in asthma control as well as better asthma-related quality of life and lung function with tezepelumab.1

Findings of a phase 2b clinical trial of astegolimab (ClinicalTrials.gov Identifier: NCT02918019) was published in the Journal of Allergy and Clinical Immunology in April.2 The trial found that astegolimb reduced adjusted asthma exacerbation rates relative to placebo by 43%. In the multicenter randomized trial in 15 countries, 502 adults with poorly controlled severe asthma, 18 to 75 years old, were subcutaneously administered 1 of 3 doses of astegolimab or placebo every 4 weeks for a year. A broad population of patients saw improvement, including those who were eosinophil-low.2

Astegolimab has yet to complete phase 3 trials. “I’m guessing that’s not something that’s going to be available in the next 6 to 8 months, maybe not even the next 12 months, depending on what the studies show and then how long it takes to get approved through the FDA,” he said. Dr Romeo. “But I love that there is another drug in development directed at one of these cytokines.”

Both tezepelumab and astegolimab “fit into the broader shift towards our understanding of the bronchial epithelium,” noted Dr Romeo. “We used to focus a bit more downstream, a little further along in the inflammatory cascade, at some of these later proteins that get developed that drive the inflammation in asthma. We are gaining a greater understanding of how important the respiratory epithelium is in creating the inflammation in asthma.”

Beyond these novel monoclonal antibodies, another major development in the management of asthma during the past year was the revision of the Global Initiative for Asthma guidelines,6 which came on the heels of the 2020 update of the National Asthma Education and Prevention Program guidelines.7 These updates had been long-awaited, said Dr Romeo.

One of the “more dramatic shifts we’ve seen in recommendations as far as managing asthma” in these guidelines is a push “to get away from using albuterol as a rescue medication and instead to consider using a low-dose inhaled steroid combined with formoterol ,” said Dr Romeo. “Data has come out over the last few years that showed that by using these combo products of inhaled steroids with a long-acting beta-agonist, we were actually able to achieve a similar level of asthma control, or sometimes even superior asthma control, and it helps in preventing people from overusing their rescue inhalers as a kind of maintenance. Now you can actually use the same inhaler for both maintenance and rescue, adjusting the frequency and sometimes the dosage of the medication based on symptoms.”

Another consequential development in asthma care evident in the new asthma guidelines is an emphasis on developing a precision medicine approach to asthma control. Instead of “having blanket recommendations for all people with asthma,” clinicians are being encouraged to “more precisely treat the individual,” said Dr Romeo.

“There’s a lot of research going on right now,” he added. “The consortium PrecISE [Precision Interventions for Severe and/or Exacerbation-Prone Asthma Network] (ClinicalTrials.gov Identifier: NCT04129931) is enrolling a lot of patients and trying to learn about different biomarkers that identify people with certain subtypes of asthma to do more targeted therapy for the individual.8 There’s a big push in medicine in general, but certainly in asthma, to start to home in on biomarkers that tell us what’s driving asthma from a genetic or environmental standpoint and then, over time, that will allow us to devise treatments that will more individually treat patients.”

Dr Romeo also foresees that some of the newer asthma drugs could be utilized in younger populations of patients. “For some [of these drugs]like omalizumab,9 which is Xolair, and benralizumab,10 which is Fasenra, they’ve done real-world studies, where they actually see how effective the medication is, retrospectively looking at people who were put on the drug and not in any kind of clinical trial setting,” he explained. The studies have confirmed “that these drugs do continue to work even if it’s not perfect conditions. I think there’s going to be a push to try to get younger populations [using] these drugs because they’re just so effective, and for young kids we don’t have a lot of additional options outside of inhalers and steroids right now.”

References

1. Menzies-Gow A, Corren J, Bourdin A, et al. Tezepelumab in adults and adolescents with severe, uncontrolled asthma. N Engl J Med. 2021; 384(19):1800-1809. doi: 10.1056/NEJMoa2034975

2. Kelsen SG, Agache IO, Soong W, et al. Astegolimab (anti-ST2) efficacy and safety in adults with severe asthma: a randomized clinical trial. J Allergy Clin Immunol. 2021;148(3):790-798. doi: 10.1016/j.jaci.2021.03.044

3. FDA approves Tezspire™ (tezepelumab-ekko) in the US for severe asthma. News release. Amgen. December 17, 2021. Accessed January 7, 2022. https://www.multivu.com/players/English/8812852-amgen-fda-approval-tezepelumab-severe-asthma-inflammation/

4. Tezspire. package insert. Amgen; 2021. Accessed January 7, 2022. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/761224s000lbl.pdf

5. Park, B. Tezspire approved as add-on maintenance treatment for severe asthma. MPR. Dec. 20, 2021.

6. Reddel HK, Bacharier LB, Bateman ED, et al. Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes. Eur Respir J. 2021;59(1):2102730. doi:10.1183/13993003.02730-2021

7. Expert Panel Working Group of the National Heart, Lung, and Blood Institute National Asthma Education and Prevention Program Coordinating Committee (NAEPPCC). 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group. J Allergy Clin Immunol. 2020;146(6):1217-1270. doi:10.1016/j.jaci.2020

8. Ivanova A, Israel E, LaVange LM, et al. The precision interventions for severe and/or exacerbation-prone asthma (PrecISE) adaptive platform trial: statistical considerations. J Biopharm Stat. 2020;30(6):1026-1037. doi: 10.1080/10543406.2020

9. Bousquet J, Humbert M, Gibson PG, et al. Real-world effectiveness of omalizumab in severe allergic asthma: a meta-analysis of observational studies. J Allergy Clin Immunol Pract. 2021;9(7):2702-2714. doi: 10.1016/j.jaip.2021.01.011

10. Kavanagh JE, Hearn AP, Dhariwal J, et al. Real-world effectiveness of benralizumab in severe eosinophilic asthma. Chest. 2021;159(2):496-506. doi: 10.1016/j.chest.2020.08.2083