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I Really Want to Know You!

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I want to know you. The real you. Everything about you.

You captivated me the minute I first saw you on my morning commute. I have never seen someone so gorgeous get stuck between the train doors like that. The doors Heimliched one of those hefty Ricola cough drops out of your mouth and into mine, and it lodged in my windpipe. I choked, but tried to play it cool by returning to drafting an e-mail to the animal shelter about how it needs to take my dipshit dog back before I abandon her in an IKEA for some horrible family to take pity on. Is it not fate that you and I both love and/or like and/or tolerate honey lemon?

Be vulnerable with me. No shallow stuff. I didn’t wiretap your phone to hear you make small talk. What’s your relationship history like? Have you ever hurt anyone? I have, but only with my car. And it was a rental, so it doesn’t count.

“What’s your deal?!” you scream in my face. God, we’re so similar. That’s what I want to ask you. Do you have siblings? A job? What are your parents like? I’m sure I’ll get a chance to ask after I’m done mugging you. Your brawny arm reaches around to your back pocket as the barrel of my gun bounces against your chest. “Stop it!” you shout. You never say “I have a family!” or “Tell my girlfriend I love her.” I’ve never blushed this hard while wearing a ski mask. Finally, a good man who’s single.

You’re so full of mystery. Your ID says you’re from Delaware. What could that possibly mean?

What do you think of me? I return your wallet because I am, above all, a good person. There were only ones in there anyway. You tell me that I look familiar. I bet you’ve seen me in the park district’s PSAs on kayak safety (“Girl #3 Brutally Capsizing”). You tell me I look like the girl in your recurring nightmare in which your co-worker’s whole family is mad at you at the Cheesecake Factory. The girl lurks in the parking lot and hisses. I would not personally recommend this as a way to ask someone out, but it is a fascinating insight into your psyche.

I want to know everything about you, or at least enough to get the gist. Properly and safely consuming a banana split takes two hands and full mental energy. God, this thing is huge. Do banana splits usually have blueberries, or is this what I think it is, a modern twist on an old classic? You’ve been talking quite a bit on our first date, but I’ve tuned out. You mentioned something a while ago about having a lot of debt, but I’ll fill in the blanks later, like I did on jury duty. I tune back in when you ask me if I’ll help you. I’ve never helped anyone before, but I’m sure I’ll be good at it.

Relationships are all about trust, so I trust that you’ll understand why I was a little late (two hours) to the funeral service we’re holding after faking your death. I had a doctor’s appointment, which is a perfectly accurate way to characterize getting Botox at the med spa. But everything’s going as planned. I am clicking through a slide show of every picture I’ve taken of you when you weren’t looking, and talking way louder when I hear you snoring from the closed casket. Your mother just turned to some lady and asked, “Who is this bitch?” An angry man no one seems to know seethes at the end of the farthest pew. I cannot move my face. Remember when Colin Powell died? I was just thinking about that. I might try micro-needling next.

What are your life’s greatest accomplishments? I wish I had asked you before running out of things to say during the eulogy. I pivot to talking about how it was a human-rights violation for the grocery store to ban me for juggling produce, especially when it was only moderately violent, and much of the violence was actually perpetrated against me, when employees pelted me with oranges.

Can you relax? We deserve a vacation. We deserve this Cape Cod beach. No one can hurt us here. The angry man from the pew is marching toward us, but I’m sure he’s wielding that knife at someone behind us.

I want to know everything about your body. I know it’s not ideal to be blindfolded and thrown into a trunk, but do you mind shifting a little to your right? I need more room. Can you stop freaking out? It’s really difficult for me to handle, given that I’m a bad listener.

Do you dream? I want to build our lives together, retire together, and, if we ever get out of this padlocked basement, defraud investors together, in one of those white-collar scandals that get covered by Bloomberg. Maybe we will spend Saturday mornings making mimosas and French toast. If your nose doesn’t stop whistling soon, I swear to God, I will kill you.

I’ll never rest until I know everything there is to know about you. What’s your name again? ♦

Allergy Treatment Market was valued at $17,773.4 Mn in 2021 and is forecast to reach a value of $27,347.4 Mn by 2028 at a CAGR of 6.4% between 2022 and 2028 | ALK-Abello AS, AbbVie Inc. (Allergan), Allergy Therapeutics PLC

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An allergic reaction is an immune system response to a substance that doesn’t bother the majority of other people. When a person responds to environmental elements that are typically safe for most people, allergies may result. Allergens are these compounds, which can be found in some medications, dust mites, foods, pollen, ticks, pets, molds, insects. The severity of allergy symptoms can range from moderate (rash or hives), to life-threatening (runny nose, itching, and watery/red eyes). Depending on what a person is allergic to, an allergy might have different treatments. Pharmacies sell medications without a prescription for those with minor allergies. Drugs of the antihistamine family are frequently used to treat allergies. Decongestants are a short-term therapy option. Creams and lotions are used to treat skin that has become red and itchy due to an allergic response. The inflammation brought on by an allergic response can be lessened using steroids. Natural therapies, over-the-counter (OTC) medications, and prescription medications can all be used to manage seasonal allergies.

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Market Statistics

The market for allergy medications was valued at $17,773.4 Mn in 2021 and is anticipated to grow at a CAGR of 6.4% from 2022 to 2028 to reach US$ 27,347.4 Mn.

In terms of volume, North America accounted for 38.5% of the global market for allergy treatments in 2020, followed by Europe and Asia Pacific, in that order.

Recent Developments

An exclusive licencing contract for the commercialization of Glenmark Pharmaceuticals’ ground-breaking nasal spray RYALTRIS, which is currently being evaluated by Health Canada, was signed in March 2021 by Glenmark Pharmaceuticals and Bausch Health Companies Inc.

The release of three new over-the-counter (OTC) Refresh Relieva medications was announced by Allergan PLC in October 2019. Refresh Relieva, Refresh Relieva for Contacts, and Refresh Relieva PF multidose.

Dr Reddy’s Laboratories introduced levocetirizine dihydrochloride tablets, a treatment for allergies, in the United States in March 2018. According to Dr Reddy’s Laboratories, the US Food and Drug Administration has authorized its “launch of levocetirizine dihydrochloride tablets USP, 5 mg, an over- the-counter therapeutic comparable generic form of UCB’s “Xyzal allergy pills” (FDA).

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Market Drivers

During the projected period, a high prevalence of disorders worldwide is anticipated to fuel market expansion for allergy treatments. The most prevalent allergic illnesses affecting children today include atopic dermatitis, food allergies, allergic rhinitis, and asthma. For instance, nearly 50 million Americans encountered various sorts of allergies each year, according to the Asthma and Allergy Foundation of America (AAFA). The sixth most common cause of chronic disease in the United States is allergies. One of the most prevalent health problems affecting children in the US are allergies.

Regulatory agencies often approving new medications are anticipated to fuel market expansion for allergy treatments globally over the course of the projected period. Due to the rising frequency of allergic disorders worldwide, there is a growing need for safe and efficient treatments. For instance, the Food and Drug Administration (FDA) authorised Palforzia in January 2020 to lessen allergic responses that might arise from unintentional exposure to peanuts. When a verified diagnosis of peanut allergy is present, treatment with Palforzia may be started in patients 4 years of age and older and continued in those who are older.

Market Restraints

The development of the worldwide market for allergy treatments is anticipated to be hampered by a lack of public understanding of allergy immunotherapy. Even though the prevalence of allergic allergies among people has significantly increased, disorders are still widely underdiagnosed and underestimated due to a lack of knowledge, both in developed and developing countries.

The rise in popularity of using biosimilars is anticipated to impede market expansion for allergy treatments worldwide. A biosimilar is a biologic reference product that has already received FDA approval and is very similar to it but not an identical replica. The number of biological medications has exhibited a constant and exponential growth pattern. The FDA has so far given its approval to 36 biosimilars. The newest biosimilar received approval on May 26, 2022.

Market Opportunities

Players in the worldwide allergy treatment market could benefit from attractive development prospects as environmental pollution levels rise. For instance, it is now known that air pollution is more strongly associated with a rise in the incidence of allergies. It may also make allergic rhinitis symptoms worse. According to studies, air pollution contributes to the deterioration of asthma symptoms. As a result, the incidence of allergy disorders is rising along with the degree of pollution. The need for allergy therapy is thus anticipating to rise as a result.

For companies in the worldwide allergy treatment market, rising patient awareness of allergy immunotherapy (AIT) is anticipated to provide attractive development prospects. A common long-term treatment for many patients with allergic asthma, allergic rhinitis, or stinging insect allergy is allergen immunotherapy, often known as allergy injections and conjunctivitis (eye allergy). A series of injections of the allergen is used in allergy shots, a type of immunotherapy. It serves as a preventative measure for substance allergies.

Market Trends/Key Takeaways

The global market for allergy treatments is anticipated to develop as a result of rising consumer demand for safe and efficient products. For instance, Nicolan Healthcare announced the introduction of antibiotics in August 2021 for the management of different allergy symptoms as well as the treatment of infections and infections.

The global market for allergy treatments is anticipated to expand as a result of the rising development of innovative allergic remedies. As an illustration, immune system researchers are starting to comprehend the underlying causes of allergies and developing next-generation medicines that could prevent allergies entirely rather than just treating their symptoms. Additionally, businesses and private investors are flooding the market with cash.

Competitive Landscape

Includes Teva Pharmaceutical Industries, ALK-Abello AS, Stallergenes Greer PLC, AbbVie Inc., Novartis International AG, Sanofi SA, Allergy Therapeutics PLC, Dermapharm Holding SE, Bausch Health Companies Inc., Johnson & Johnson, Leti Pharma, Alembic Pharmaceuticals Limited, GlalinexoS PLC, and Hoffmann-La Roche Ltd, Nicox SA.

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Reasons to buy this Allergy Treatment Market Report

☑ It attempts an analysis of the competing scenario.

☑ The current and exceptional product revenue market.

☑ An in-depth data on the regional investigation and competitive landscape structure.

☑ It benefits in creating an awareness of the important key product segments.

☑ The marketing strategies, opportunities, and development factors are explained.

☑ Allergy Treatment market size estimation and recent advancements in the industry are explained.

The Study Objectives are:

✔ A comprehensive insight into key players operating in the Allergy Treatment Market and their corresponding data.
✔ It includes product portfolio, annual revenue, expenditure on research and development, geographical presence, key developments in recent years, and growth strategies.
✔ Regional analysis, which includes insight into the dominant market and corresponding market share.
✔ It also includes various socio-economic factors affecting the evolution of the market in the region.
✔ The report offers a comprehensive insight into different individuals from value chains such as raw materials suppliers, distributors, and stockholders.

Table of Content

Chapter 1 Industry Overview
1.1 Definition
1.2 Assumptions
1.3 Research Scope
1.4 Market Analysis by Regions
1.5 Allergy Treatment Market Size Analysis from 2022 to 2028
11.6 COVID-19 Outbreak: Allergy Treatment Industry Impact

Chapter 2 Global Allergy Treatment Competition by Types, Applications, and Top Regions and Countries
2.1 Global Allergy Treatment (Volume and Value) by Type
2.3 Global Allergy Treatment (Volume and Value) by Regions

Chapter 3 Production Market Analysis
3.1 Global Production Market Analysis
3.2 Regional Production Market Analysis

Chapter 4 Global Allergy Treatment Sales, Consumption, Export, Import by Regions (2017-2022)
Chapter 5 North America Allergy Treatment Market Analysis
Chapter 6 East Asia Allergy Treatment Market Analysis
Chapter 7 Europe Allergy Treatment Market Analysis
Chapter 8: South Asia Allergy Treatment Market Analysis
Chapter 9 Southeast Asia Allergy Treatment Market Analysis
Chapter 10 Middle East Allergy Treatment Market Analysis
Chapter 11 Africa Allergy Treatment Market Analysis
Chapter 12 Oceania Allergy Treatment Market Analysis
Chapter 13: South America Allergy Treatment Market Analysis
Chapter 14 Company Profiles and Key Figures in Allergy Treatment Business
Chapter 15: Global Allergy Treatment Market Forecast (2022-2028)
Chapter 16 Conclusions
Research Methodology

Customization of the Report

Our research analysts will help you to get customized details for your report, which can be modified in terms of a specific region, application or any statistical details. In addition, we are always willing to comply with the study, which triangulated with your own data to make the market research more comprehensive in your perspective.

About Us:

Coherent Market Insights is a global market intelligence and consulting organization that provides syndicated research reports, customized research reports, and consulting services. We are known for our actionable insights and authentic reports in various domains including aerospace and defense, agriculture, food and beverages, automotive, chemicals and materials, and virtually all domains and an exhaustive list of sub-domains under the sun. We create value for clients through our highly reliable and accurate reports. We are also committed in playing a leading role in offering insights in various sectors post-COVID-19 and continue to deliver measurable, sustainable results for our clients.

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How effective are live-attenuated SARS-CoV-2 vaccines?

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In a recent review published in PLoS Pathogensresearchers opened on the use of live-attenuated whole virus vaccines (LAV) as coronavirus disease 2019 (COVID-19) vaccines.

Study: Can live-attenuated SARS-CoV-2 vaccine contribute to stopping the pandemic? Image Credit: WESTOCK PRODUCTIONS/Shutterstock

Background

The COVID-19 pandemic has caused significant mortality and morbidity across the globe, warranting the development of effective therapeutic vaccines and drugs to curtail severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. Several COVID-19 vaccines are being administered and have demonstrated anti-SARS-CoV-2 efficacy; However, the continual emergence of SARS-CoV-2 variants of concern (VOCs) has threatened vaccine efficacy.

Current vaccines are based on rapid vaccine platforms such as messenger ribonucleic acid (mRNA), adenovirus vectors, deoxyribonucleic acid (DNA) vectors, and inactivated and protein subunit vaccines. In the face of rapidly emerging VOCs, vaccine platforms with long development durations and pathways have been largely overlooked.

Novel vaccines are required to induce long-term emerge and broader immune protection against current SARS-CoV-2 VOCs and those yet to. An intranasal (in) single-dose LAV vaccine is being developed by Codagenix and Serum Institute of India and has finished Phase I clinical trials with promising immunogenicity and safety.

In the present work, researchers reviewed LAV vaccines and their efficacy against SARS-CoV-2.

Applications and immunogenicity of LAV vaccines

Most of the vaccines authorized to prevent viral infections are LAV vaccines. They have been used for decades to provide long-term immunity against several viruses, such as the herpes zoster virus (HZV), poliovirus, and yellow fever virus. Smallpox vaccines have been effective and are based on the vaccinia virus, a LAV virus related closely to the variola virus. Other LAVs used routinely include mumps, measles, rubella, rotavirus, and chickenpox.

Current COVID-19 vaccines (such as BNT162b2) are administered intramuscularly (im), wherein the site of injection is distant from the site. As a result, strong immunoglobulin G (IgG) responses and robust systemic immunity is generated, but poor mucosal immunity. In addition, the im injections do not generate tissue-resident B and T lymphocytes, and high shedding can occur post-vaccination, causing breakthrough SARS-CoV-2 infections. Moreover, vaccination-induced immune responses are not as potent as those induced by natural infections and wane rapidly.

In contrast, LAV vaccines are administered intranasally at the site of SARS-CoV-2 entry and generate strong IgG and IgA titers with potent systemic and localized (mucosal) immunity. Additionally, strong tissue-resident lymphocytes (memory B lymphocytes and T lymphocytes) are generated by the in route, with low viral shedding, reducing the risk of breakthrough infections.

Ly, LAVs mimic natural infections and result in robust and durable immunity, important to those induced by natural infections. Further, the in route is potentially faster, simpler, and more cost-effective than the currently administered vaccines and, therefore, highly desirable for widespread and swift global vaccination coverage. Additionally, LAV vaccines can be administered by the subcutaneous (SC) route, a delivery route that effectively induces systemic immune responses and could broadly and comprehensively boost immunity post-primary vaccination.

LAV vaccine efficacy against SARS-CoV-2

Vaccines directing immune responses against only one SARS-CoV-2 structural protein, usually the spike (S) protein induces narrower responses than vaccines inducing immunity against the live virus. Therefore, emerging S variants may readily escape the targeted vaccine-induced immune responses since they don’t include additional SARS-CoV-2 epitopes and may not induce broad and cross-reactive immunity against the continually emerging SARS-CoV-2 variants. Therefore, current vaccines may require to be constantly updated and modified based on SARS-CoV-2 evolution.

LAV vaccines induce broad and cross-reactive immune responses by inducing T lymphocyte and B lymphocyte epitopes for all SARS-CoV-2 proteins, are effective against conserved regions in SARS-CoV-2, and the LAV vaccine efficacy has a lower likelihood of being impacted by viral alterations. Particularly, LAV vaccines induce robust CD8+ (cluster of differentiation 8+) T lymphocyte responses and may generate strong tissue-resident memory T lymphocytes (T).RM).

Conclusions

To conclude, based on the review findings, Immune responses against SARS-CoV-2 can be induced by natural infections or vaccinations. While currently used SARS-CoV-2 S-targeted and intramuscularly administered mRNA COVID-19 vaccines are effective against the virus, less efficacy has been demonstrated against the highly immune-evasive and transmissible Omicron variant. Further, mRNA vaccination-induced immunity has been reported to be lower than that induced by natural infections and wane quickly.

In contrast, entire virus-targeted and intranasally administered LAV vaccines can confer broad, cross-protective, and long-term immunity against SARS-CoV-2 and is less likely to be affected by emerging SARS-CoV-2 variants. LAV vaccines could induce localized and systemic immune responses and, therefore, could effectively boost immunity conferred by primary vaccinations; However, LAV vaccines are not recommended for immunocompromised individuals.

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7 Ways to Become a Digital Nomad in 2022

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This way or the other, becoming a digital nomad is very likely to be a smart decision that might change your life.

Being a digital nomad is the new dream job. The idea of ​​working from a coffee shop or a tropical beach and traveling around the world is tempting for everyone. But to become a digital nomad, you must have a type of job that enables you to work remotely while traveling.

If you are unsure how to start your journey to living the digital nomad life, in this article, we suggest some of the best digital nomad jobs as of 2022.

7 Popular Digital Nomad Jobs to Travel the World

Below, we’ve listed the most trending digital nomad jobs in 2022 and beyond that can be done from any place around the world.

Freelance Content Writer

With so many websites and digital channels out there, it is not surprising that a freelance content writer is one of the best remote jobs you can find. If you have the self-discipline and the skills to do it, you can easily get a few clients and create a solid income that will allow you to travel the world.

What you need to do is to find a niche that you can focus on and understand how online writing works in terms of content structure. Then, you can create your own business by building your writing portfolio and sending it to different clients. Of course, there is a catch-22 here, but because of the high demand for content writing, you’ll be able to solve it quickly if you do things the right way.

Trading Financial Markets

Due to many online trading applications that popped up in the past few years, there are also many digital nomads who trade for a living. Many of these traders do it with their capital, though you must be an experienced trader with a proven track record and a successful trading strategy.

But fortunately, there are great solutions these days for beginner traders with no experience and knowledge in trading. One of these includes proprietary tradingwhich essentially refers to trading firms that allocate their capital to prop traders.

A prop trading firm offers talented traders the ability to trade with a fully funded trading account. You basically have to register and go through a short questionnaire before getting access to the company’s trading platform and capital. Then, once you have finished the evaluation period with a profit and proved your ability to trade the markets successfully, you get a more significant amount of capital to trade the real live markets.

In sum, it is an excellent way to travel and earn money. In fact, if you are a good trader, you can finish your digital nomad days with some extra cash in your bank account.

Busking (Street Performance)

Busking??? Yes, busking. Busking is basically playing music in a public place for tips. Many musicians dream of performing on the streets and earning money on their travels by busking. It is just an authentic way to get your music out there and create a unique vibe in some corner of the world.

So, if you have musical talent and enough confidence to play in public, busking could be a great way to make money and be location independent.

Traveling Blogger

Honestly, what can be better than traveling and sharing your experiences with your readers? Fortunately, travel blogging has become so popular in the past few years, and anyone who wants to share tips and travel ideas can potentially succeed.

But, of course, it’s not easy. First, you need to choose the medium to deliver your message. It can be a blog, a Facebook or Instagram page, or even a channel on popular websites that allow you to do that (Medium, Quora, Linkedin, etc.). But, regardless of the medium, you decide to share your traveling tips, you must know how to get traffic and, more importantly, monetize your channel. That’s the big challenge in making a traveling blog – to make a passive income. Some bloggers review products, add affiliate links or make sponsored videos. Otherwise, if you are not the type of person that knows how to sell, you can use social media managers or digital marketing managers to make the most out of your travel blog.

Still, we suggest reading and understanding how blogging works before you put effort into creating a blog. Blogging is not for everyone, especially if you are planning to make money out of it.

Programmer/Web Developer

If you have the skill of writing codes or creating and maintaining websites, you can practically do it anywhere in the world. Nowadays, programming is one of the most demanded skills and is certainly a rewarding job. This means that if you can get a remote developer job, you can choose any location you want to work at and explore new places.

Virtual Assistant

If you have excellent administrative and technical skills, working as a virtual assistant can be an easy way to get a remote work job. This role includes different tasks such as scheduling appointments, sending and organizing emails, making phone calls, arranging travel, managing contact lists, and doing market research.

Luckily for those who wish to become virtual assistant remote workers, there’s a growing demand for virtual assistants in recent years. According to TrueListthe IT outsourcing industry is expected to grow by roughly 4.5% between 2020 and 2025.

Therefore, finding a digital nomad job as a virtual assistant is reasonably easy. So, if you have no idea what you want to do for a living but just want to travel for a while, a virtual assistant can be the ideal job to explore the digital nomad lifestyle.

Video Producer

Finally, becoming a video producer is another great digital nomad job that will enable you to work from anywhere you’d like. A Video Producer is responsible for planning and creating all of the elements of video production from start to finish. It’s an exciting job that can be done remotely, which means you can do it from anywhere in the world. Best of all, with so many new tools to produce video content, It is possible for any individual with no time and editing skills to produce high quality videos.

And, with the increasing demand for videos on different social media platforms, you can expect to find many projects to work on while traveling.

Summary

In summary, becoming a digital nomad will give you the opportunity to work and live anywhere. So, if you are keen to become a digital nomad, all that is left for you to do is choose the right job that will help you reach your goal and build your digital nomad business.

Our list above can be valuable for you, but remember that there are other highly demanded jobs for digital nomads. These include a social media manager, social media marketer, SEO specialist, graphic designer, digital marketing agent, and many more. Obviously, you’ll have to get familiar with freelance platforms and job boards like Upwork, PeoplePerHour, and Fiverr. Otherwise, you can contact tech companies and online businesses directly to find remote job opportunities.

Having said that, you also need to keep in mind that many people choose a particular digital nomad job for a limited time to explore the world and expand their horizons. For instance, you can decide to become a street performer or a financial trader for several years to live in an exotic place and then return to your regular job. Or, you can stay in your current job and ask your manager to work remotely for a while. It’s very flexible as long as you have a goal and want to experience the digital nomad lifestyle. This way or the other, becoming a digital nomad is very likely to be a smart decision that might change your life.

Press Release Distributed by The Express Wire

To view the original version on The Express Wire visit 7 Ways to Become a Digital Nomad in 2022

TolerogenixX Publishes Three-Year Follow-Up Data from Phase I Trial of Immune Tolerance-Inducing MIC-Lx Cell Therapy

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Heidelberg, September 26, 2022 – TolerogenixX GmbH, a biopharmaceutical company developing personalized cellular therapies aimed at achieving sustained immune tolerance to combat organ rejection and autoimmune diseases, today announced 3-year follow-up data of a Phase I trial of its MIC-Lx cell therapy. The results published ahead of print in the Journal of the American Society of Nephrology (doi: 10.1681/ASN.2022020210) indicate that donor-specific immunosuppression after MIC infusion is long-lasting and associated with a striking increase in regulatory B lymphocytes.

MIC cell treatment is a curative approach to achieve a sustained regulation of the immune system in transplant recipients and autoimmune patients. In the process for living donor transplantation, peripheral blood mononuclear cells (PBMCs) of the donor are obtained by leukapheresis. PBMCs are then modified using TolerogenixX´ proprietary MIC technology. Subsequently, the resulting cell therapy product called MIC-Lx is intravenously administered to the organ recipient prior to transplantation.

The publication reports results from a follow-up to post-transplant day 1080 in 10 transplant recipients from a Phase I clinical trial who had received MIC infusions prior to kidney transplantation. All MIC-treated patients had a favorable clinical course, showing no donor-specific human leukocyte antigen antibodies or acute rejections. The four patients who had received the highest MIC cell dose 7 days before surgery and were on low immunosuppression showed persistent donor-specific immunosuppression as indicated by an absence of post-transplant cellular stimulation reactivity when tested against their respective donors. Likewise, a number of markers, including gene expression profiles, suggest operational tolerance in these patients, ie no need for immunosuppression and normal allograft function.

“MIC treatment is leading to an operationally tolerant phenotype of patients with profound suppression of anti-donor T cell responses,” said Prof. Dr. Christian Morath, CSO of TolerogenixX. “The one-year follow-up data published in 2020 already showed excellent safety and tolerability of our treatment, and we are very happy that these favorable results hold up in the three-year follow-up.”

“The results once again demonstrate that we generate an immunoregulatory cell population which carries the promise of exerting a beneficial effect on kidney transplants,” added Prof. Dr. Matthias Schaier, CEO of TolerogenixX.

PD Dr. Anita Schmitt, CTO of TolerogenixX, said: “These new results show that the effect is long-lasting and associated with a striking increase in regulatory B lymphocytes. They underline the importance of MIC-Lx in paving the way for a novel cell therapy in organ transplantation.”

A multi-center Phase IIb trial codenamed TOL-2 enrolling 63 transplant couples consisting of a donor and a transplant recipient is underway.

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About TolerogenixX

TolerogenixX is a privately held biopharmaceutical company focusing on the development of novel, personalized therapies for autoimmune patients and transplant recipients. The Company´s proprietary MIC (modified immune cells) treatment is designed to suppress unwanted immune responses in the body, enabling a targeted, specific and sustained immune tolerance. While the current standard of care, ie traditional immunosuppression, is only addressing symptoms and has serious side-effects, MIC treatment is tackling the roots of immune responses and provides increased effectiveness, little or no side effects, significantly increased quality and length of patients´ lives as well as determining cost advantages.

TolerogenixX´ lead compound MIC-Lx has successfully completed a clinical Phase Ib trial in kidney transplant recipients, demonstrating sustained safety and tolerability after a single application while retaining normal immune responses.

The Company was founded in 2016 and is based in Heidelberg, Germany.

About MIC treatment

MIC treatment is a personalized cell therapy approach modulating the immune system via a novel mode of action to achieve a specific and sustained immune tolerance. It can not only be applied to transplant recipients, but also to patients with autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

MIC production is fast, safe, and effective. MIC can be manufactured within 12 hours, using cells obtained by leukapheresis. Due to a standardized procedure, MIC production can be scaled up easily and made available globally using the proprietary approach developed by TolerogenixX.

Contact
TolerogenixX GmbH
Prof. Dr. med. Matthias Schaier
Im Neuenheimer Feld 162
D-69120 Heidelberg/Germany
[email protected]
Tel. +49 162 2638005

akampion
Dr. Ludger Weß / Ines-Regina Buth
Managing Partners
[email protected]
Tel. +49 40 88 16 59 64
Tel. +49 30 23 63 27 68

Css Founder : A Maverick Website Design Company in Chennai

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Everyone needs a website for their company in order to conduct business globally, CSS Founder is a firm that recognises the potential of a website in expanding the horizon of opportunities for it and therefore provides holistic assistance to businesses in building a user and SEO friendly website.

CSS Founder is rated as the best website design company in Chennai Because it has evolved as a brand in the industry with rapidly advancing technology of the digital era. A reputable web design company, CSS Founder, utilises cutting-edge and reliable solutions to assist firms in growing their businesses. With the motto “Website For Everyone,” CSS Founder is one of the best and most reliable website design companies, having worked on thousands of projects. Css Founder ranked top on Google with Website Designing company in Bangalore keyword Thus with the help of Google ranking they are making monopoly in website industry.

“Our team works around the clock to ensure that all the website deliverables are met as per the client requirements. We are aware that a website can lead to increased sales, boost earnings, and expand a business, one must have a professional-looking, brand-differentiating website. Your website can help you generate income, boost brand awareness, spread goodwill among customers and target markets, and provide effective marketing cues. , ” says the team at CSS Founder in a statement.

Today, the firm sustains its reach in the United Arab Emirates, India, the United States, and other continents. The firm has developed websites for a wide range of national and international brands, major corporations, and even small businesses. Given how crucial it is for you to have a website built as soon as possible, the seasoned team of designers equip their experience to finish every job quickly and on schedule.

CSS Founder has also developed apps for a variety of clients in the industry as an expert app designer. One example of their app development success is a well-known global business. In order to stand out in a crowded industry and have a greater influence on more customers than ever before, CSS Founder helped them revitalize their app materials.

What separates CSS Founder as a trusted partner is their ability to assist clients in establishing relevant and customized solutions. Regardless of the capacity of a business, CSS Founder has empowered every business to have a website and partner with them. The extensive portfolio of CSS Founder showcases their prior experience as seasoned professionals.

Apart from this, their “Free Food for Needy Children” has also been sending the message of contributing to the health of the needy since 2016. He has tirelessly campaigned for this cause, frequently spending days with people in the slums of Delhi-NCR or along the city’s motorways. His weekly scheduling of these sessions sets him apart with the only goal being to bring joy and happiness to those who are less fortunate. Imaran believes that if those of us who are fortunate enough to be able to provide for some children take on this responsibility, a day will come when no child in the nation will go to bed hungry.

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Marking 20 years of writing food column

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This week brings us into autumn already. It also always takes me back to 20 years ago, when my dear mother so suddenly passed away. She died Sept. 17 in Blue Springs, Missouri. The funeral wasn’t until Sept. 23.

My mother penned this column for 11 years, and after her death I started writing. Joe and I had six children at the time, and Joseph was eight weeks old. Where have all the years gone to? Time does not stand still. I have many precious memories of my sweet mother. She far outdid me in cooking/baking.

Yesterday we did laundry, and I had everything hung outside, then I heard thunder in the distance. I gradually took off the clothes as they dried, but the storm kept getting closer. I hung what fit on the lines on the porch, then brought the rest in baskets inside. We didn’t get too much thunder and lightning, but some rain.

Are Arnold Schwarzenegger and Maria Shriver still friends?

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Professional bodybuilder-turned-Hollywood star Arnold Schwarzenegger and American journalist Maria Shriver split after almost 25 years of marriage in 2011. However, they didn’t legally divorce for 10 years until 2021.

It was days after their separation announcement in 2011 that the story of Arnold Schwarzenegger fathering a child with long-time housekeeper Mildred Baena in 1996 broke out. Apparently, Schwarzenegger came clean to Shriver during a couples therapy session a day after his term as the Governor of California came to an end.

Despite these hurtful and ugly circumstances, the couple remained a family unit and were devoted parents to their four children Katherine, Christina, Patrick, and Christopher. Over the years, they have maintained a friendship for the sake of their kids, whom they described as the “light and the center” of their lives. They had said:

“We are continuing to parent our four children together.”

They even celebrated the Terminator star’s birthday together in 2020 and Shriver also wished him a Happy Father’s Day that year in a social media post. Posting a picture of him posing with their four children, she wrote:

“Happy Father’s Day to all the dads here on earth who father day in day out, and to you, Arnold. We all wish you the happiest Father’s Day!”

Arnold Schwarzenegger and Maria Shriver are dedicated grandparents to Katherine’s daughters with actor Chris Pratt, Lyla Maria and Eloise Christina. Both of them also celebrated son Patrick’s 29th birthday together this year.

In 2018, Shriver released a self-help book titled, I’ve Been Thinking… : Reflections, Prayers, and Meditations for a Meaningful Lifewherein she discussed embracing her new normal.

“I do admire people who work at their marriages, but I also admire those who chart a new way forward. And I really admire those who manage to stay friends after their marriages are over — and aren’t afraid to try love again after being hurt.”

Through the toughest of personal times, the family stood unified. Shriver also spoke about how forgiveness is a process and takes time.

“Forgiveness is letting go of the need to feel like a victim. … Take it from me: If you’re struggling with forgiveness, be gentle with yourself, because I’ve learned that forgiveness is a process, and it takes time.”

After the cheating scandal broke out, Arnold Schwarzenegger admitted to his mistakes and clarified that he had apologized to Shriver, their children, and their family.

“After leaving the governor’s office, I told my wife about this event, which occurred over a decade ago. I understand and deserve the feelings of anger and disappointment among my friends and family. There are no excuses and I take full responsibility for the hurt I have caused. I have apologized to Maria, my children and my family.

Expecting an intense media reporting, Arnold Schwarzenegger asked the press to respect the privacy of Shriver and their kids.

“I ask that the media respect my wife and children through this extremely difficult time. While I deserve your attention and criticism, my family does not.”


Is Arnold Schwarzenegger close to his son, Joseph Baena?

Arnold Schwarzenneger and Joseph Baena (Image via Gala.de)

Congratulations Joseph! Four years of hard work studying business at Pepperdine and today is your big day! You have earned all of the celebration and I’m so proud of you. I love you! https://t.co/aRuJzGzAWi

Baena wished his father on his 75th birthday this year, thanking him for inspiring him and others around the world to be “better everyday”.

Arnold Schwarzenneger is often seen with sons Joseph and Patrick in the gym. In 2019, Baena shared a gym selfie with Schwarzenegger explaining that there’s no cheating when working out with him.

“This selfie was taken moments before my dad suggested I do “forced reps” for the rest of the workout. You have to go all out and absolutely NO cheating when you train with him, so you know I’m going to be hurting tomorrow .”

It is not known if the Schwarzenegger daughters are close to Baena, but Patrick was photographed with him in April last year.



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Geeky Tech Announces Launch of Paid and Organic B2B Marketing Services

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Leading digital marketing agency, Geeky Tech, now offers data-driven SEO and PPC services to B2B enterprises in the technology, SaaS, and IT security sectors.

To help B2B technology companies skyrocket their business online with elevated brand value, Geeky Tech, a leading digital marketing agency, now offers organic and paid marketing services.

Teaming up with a data-driven SEO agency can help clients turbocharge their marketing efforts, and Geeky Tech leverages effective strategies to ensure optimal business growth. Taking a holistic approach to web marketing, this full-service digital marketing firm aims to help world-leading companies thrive in sales exposure and ROI.

As part of the B2B marketing services, Geeky Tech offers inbound marketing-focused SEO services that ensure a solid digital presence and drive targeted organic results.

The company claims that by leveraging tried-and-tested B2B SEO techniques, the experts can boost client websites to rank high in search engines and generate high-converting organic traffic for lead generation and online sales.

Considering research at the forefront of the digital marketing strategy, Geeky Tech performs comprehensive competition analysis to figure out the practices they adopt. The aim is to develop an keyword strategy that helps clients one-up the competitors and boost the volume of their inbound leads in a few months.

In addition, the company conducts a complete website audit while applying dedicated SEO techniques to ensure a client’s website is technically functional and optimized for better site speed. Aligning technical SEO with on-page optimization best practices, the SEO team at Geeky Tech makes search engine spiders crawl and index client web pages effectively for improved organic reach.

Making the most of off-page optimisation techniques, the team looks beyond a website for improved visibility and builds positive brand equity through high-authority backlinks, traffic, and mentions.

According to studies, organic search drives more than 50% of all website traffic today, and 49% of marketers say SEO offers the best ROI of any marketing channel.

Even though smart SEO techniques are guaranteed to boost search engine visibility, offer higher click-through rates, and help achieve long-term marketing goals, customers need to wait up to 3-6 months to see the real results.

For businesses trying to improve their brand exposure by reaching high-converting customers within and outside of their network, Geeky Tech has cost-effective paid media services.

The company claims it can roll out laser-targeted ad campaigns to reach the right customer base at the right time by utilizing multi-channel marketing strategies throughout the buyer journey. The benefits are many: instant traction from a particular customer segment, easily traceable results, higher ROI and customer retention rate, and so forth.

To quote a client, “The team got the landing page and ad campaign set up within a week, and we began to see our ad listing at the top of the search results immediately. While we are just a few days into the campaign, I can already see we are getting lots of new visitors that we would not have had otherwise.”

Interested parties can learn more about by visiting https://www.geekytech.co.uk/.

Contact Info:
Name: Ben Hawkshaw-Burn
Email: Send Email
Organization: Geeky Tech
Address: Parallel House 32 London Road, Guildford, Surrey GU1 2AB, United Kingdom
Phone: +44-20-3800-1212
Website: https://www.geekytech.co.uk

Release ID: 89081689

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COMTEX_415281150/2773/2022-09-26T02:05:52

TolerogenixX Publishes Three-Year Follow-Up Data from Phase I Trial of Immune … | News

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  • Publication in high-impact Journal of the American Society of Nephrology
  • Results pave the way for a novel cell therapy in organ transplantation

Heidelberg, September 26, 2022 – TolerogenixX GmbH, a biopharmaceutical company developing personalized cellular therapies aimed at achieving sustained immune tolerance to combat organ rejection and autoimmune diseases, today announced 3-year follow-up data of a Phase I trial of its MIC-Lx cell therapy. The results published ahead of print in the Journal of the American Society of Nephrology (doi: 10.1681/ASN.2022020210 ) indicate that donor-specific immunosuppression after MIC infusion is long-lasting and associated with a striking increase in regulatory B lymphocytes.

MIC cell treatment is a curative approach to achieve a sustained regulation of the immune system in transplant recipients and autoimmune patients. In the process for living donor transplantation, peripheral blood mononuclear cells (PBMCs) of the donor are obtained by leukapheresis. PBMCs are then modified using TolerogenixX´ proprietary MIC technology. Subsequently, the resulting cell therapy product called MIC-Lx is intravenously administered to the organ recipient prior to transplantation.

The publication reports results from a follow-up to post-transplant day 1080 in 10 transplant recipients from a Phase I clinical trial who had received MIC infusions prior to kidney transplantation. All MIC-treated patients had a favorable clinical course, showing no donor-specific human leukocyte antigen antibodies or acute rejections. The four patients who had received the highest MIC cell dose 7 days before surgery and were on low immunosuppression showed persistent donor-specific immunosuppression as indicated by an absence of post-transplant cellular stimulation reactivity when tested against their respective donors. Likewise, a number of markers, including gene expression profiles, suggest operational tolerance in these patients, ie no need for immunosuppression and normal allograft function.

“MIC treatment is leading to an operationally tolerant phenotype of patients with profound suppression of anti-donor T cell responses,” said Prof. Dr. Christian Morath, CSO of TolerogenixX. “The one-year follow-up data published in 2020 already showed excellent safety and tolerability of our treatment, and we are very happy that these favorable results hold up in the three-year follow-up.”

“The results once again demonstrate that we generate an immunoregulatory cell population which carries the promise of exerting a beneficial effect on kidney transplants,” added Prof. Dr. Matthias Schaier, CEO of TolerogenixX.

PD Dr. Anita Schmitt, CTO of TolerogenixX, said: “These new results show that the effect is long-lasting and associated with a striking increase in regulatory B lymphocytes. They underline the importance of MIC-Lx in paving the way for a novel cell therapy in organ transplantation.”

A multi-center Phase IIb trial codenamed TOL-2 enrolling 63 transplant couples consisting of a donor and a transplant recipient is underway.

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About TolerogenixX

TolerogenixX is a privately held biopharmaceutical company focusing on the development of novel, personalized therapies for autoimmune patients and transplant recipients. The Company´s proprietary MIC (modified immune cells) treatment is designed to suppress unwanted immune responses in the body, enabling a targeted, specific and sustained immune tolerance. While the current standard of care, ie traditional immunosuppression, is only addressing symptoms and has serious side-effects, MIC treatment is tackling the roots of immune responses and provides increased effectiveness, little or no side effects, significantly increased quality and length of patients´ lives as well as determining cost advantages.

TolerogenixX´ lead compound MIC-Lx has successfully completed a clinical Phase Ib trial in kidney transplant recipients, demonstrating sustained safety and tolerability after a single application while retaining normal immune responses.

The Company was founded in 2016 and is based in Heidelberg, Germany.

About MIC treatment

MIC treatment is a personalized cell therapy approach modulating the immune system via a novel mode of action to achieve a specific and sustained immune tolerance. It can not only be applied to transplant recipients, but also to patients with autoimmune diseases such as systemic lupus erythematosus and multiple sclerosis.

MIC production is fast, safe, and effective. MIC can be manufactured within 12 hours, using cells obtained by leukapheresis. Due to a standardized procedure, MIC production can be scaled up easily and made available globally using the proprietary approach developed by TolerogenixX.

Contact

TolerogenixX GmbH

Prof. Dr. med. Matthias Schaier

Im Neuenheimer Feld 162

D-69120 Heidelberg/Germany

[email protected]

Tel. +49 162 2638005

akampion

Dr. Ludger Weß / Ines-Regina Buth

Managing Partners

[email protected]

Tel. +49 40 88 16 59 64

Tel. +49 30 23 63 27 68

Copyright 2022 GlobeNewswire, Inc.

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