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Weight loss can be achieved with the use of the right vitamins and regular exercise. Keto Maxx aids in weight loss and the attainment of a healthy and fit body. This vitamin is effective. Exercise is critical for changing an obese body into one that appears slimmer. What is the most efficient approach to shedding pounds? Here are all of the benefits of this vitamin.

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An Overview of K1 Keto Life

Supplements can have significant negative consequences on the body, causing serious health problems. Many people have tried a variety of weight-loss approaches.

K1 Keto Life is an effective weight-loss supplement. It was developed as a consequence of extensive research and expert knowledge. Its formula contains nutrients, minerals, and other elements required for optimal physiological function.

It’s been decades since a chemical that aids weight loss was discovered. It has various health benefits, including improving metabolism, immunity, and overall well-being. It aids fat loss safely and effectively.

What Exactly is K1 Keto Life?

K1 Keto Life is a premium supplement that causes ketosis. It only has pure BHB salts in it. This product causes ketosis without requiring any dietary or exercise changes.

The mixture causes ketosis, which encourages the body to use fat instead of carbohydrates for energy.

Natural energy creation releases on fat storage. If you reduce weight, you will appear younger and more active. It can uplift your spirits and give you new vitality.

Although there are several weight reduction supplements on the market, finding the correct one can be tough. Are you in a similar situation? Don’t panic if you find yourself in the same predicament.

This K1 Keto diet helps you look more attractive. When it comes to choosing the appropriate health supplement, ladies are quite selective.

When used frequently, this product is assured of having no negative side effects. K1 Keto Life is exceptional in that it may produce remarkable outcomes in such a short period.

All of the information is available on the website. You can also browse customer reviews to ensure that you are happy with your choice.

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What is the Mechanism of K1 Keto Life or How Does It Work?

Ketosis is a tried-and-true approach for losing weight and even fighting serious illnesses. The amazing benefits of this diet come from a simple but effective carb-restricting procedure that allows your body to use fat for fuel rather than just carbs or glucose.

This keto diet will also leave you feeling vibrant, active, and full of energy thanks to its low calorie and high nutrient content. However, getting your body into a state of ketosis might be difficult. And most of us don’t have the time to meticulously follow all of the keto diet’s steps. This is where K1 Keto Life comes into play.

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K1 Keto Life employs tried-and-true ingredients to help you get into ketosis without having to go on a strict ketogenic diet for days. K1 Keto is a supplement that aids in the ketosis process. Obesity affects the majority of people around the world as a result of eating more carbohydrates while avoiding diverse proteins.

Ketosis aids weight loss by removing calories from the diet and forcing the body to use accumulated fats for energy instead of carbs. As a result, with the help of this weight reduction vitamin, one can lose weight swiftly and easily.

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How Does Ketosis Work?

Ketosis is a metabolic condition in which fat replaces carbs as a source of energy. Carbohydrates are the body’s most efficient energy source. The body will store fat if it does not have adequate carbs.

Fasting or reducing your diet encourages your body to burn calories and fat because it has no other choice.

Ketones are then used as a fuel source by the body.

K1 Keto Life maintains a steady supply of ketone sodium in the body. Ketosis is the result of this.

Before you may enter ketosis, you must follow a ketogenic diet for at least 2 weeks. K1 Keto Life is a quick approach to going into ketosis and starting burning fat naturally.

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Ingredients in K1 Keto Life

All-natural, herbal, biological, and natural ingredients are employed. Each component is carefully selected and only added following clinical testing.

Beta-hydroxybutyrate (BHB): It is the main component (BHB). BHB is a three-salt “chain” that has been combined. BHB aids fat burning in the body. BHB-containing weight loss supplements are usually effective.

Garcinia Cambogia: Garcinia Cambogia is another “great” weight-loss substance. It helps the body burn calories more efficiently. Hydroxycitric Acid (HCA), another molecule, inhibits and lowers hunger.

Apple Cider Vinegar: A high-protein diet aids in the conversion of protein to energy. It’s important to remember that BHB aids in the conversion of fat to energy.

It’s important to remember that BHB aids in the conversion of fat to energy. Caffeine increases metabolic rate while lowering lipid levels in the body.

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Baby’s eczema ‘looks like she been burnt’ – but she could face months to see a doctor


A baby whose eczema is so bad she looks like she’s been scalded with boiling water is in agony every day. Riley Bedwell is eight months old and while she has always had the skin condition it has got much worse over recent months.

Her mother, Aimee, says the tot barely sleeps because of the pain and itching. And she says nothing is helping to make the little girl better, reports Wales Online.

Aimee said the family has tried everything to reduce Riley’s skin problems, including getting rid of all cleaning products, sprays and even trying homeopathic approaches. However, none have worked.

The family has made countless visits to her GP surgery in a desperate plea for help. And now despite being given an urgent referral by their doctor to see a specialist she has been warned they could be facing a wait of months.

Aimee, from Pembrokeshire, said: “Her eczema was a lot milder when she was first born, but as time has gone on it has become worse and worse. For the past three months it has been horrific.

“She looks like she’s been burnt with boiling water – her skin is red raw. It’s on her head, face, shoulders, torso, legs – everywhere.

“It’s just incredibly painful for her. It constantly gets infected and changing her can be horrendous as her clothes just stick to her.

“It also keeps her up at night. She hasn’t slipped well for months because she wakes up itching – and then that keeps me awake. It’s like torture and it’s affecting our whole life.”

Aimee has been told it could take months, if not years, for Riley to be seen through the Welsh NHS due to the huge waiting lists. The family believes they have no option but to try and get the tot an appointment privately.

She said: “It’s incredible the amount of times I’ve sat in the doctor’s car park crying because they’ve just sent me off with more cream. I appreciate what the GPs do, and they’re helping to the best of their knowledge , but because of the pressure the NHS is under the waiting lists are ridiculous and we’re just not getting seen. This poor baby is sat here in pain with nothing else more they can do for her.”

Aimee, has also taken Riley to A&E and a minor injuries unit in the hope a breakthrough will be found, said she and her husband Bradley are now playing a waiting game. They’re also concerned about whether Riley will want to roll or crawl in the coming months as her skin is so sore.

“I know there are people worse off than her, but something needs to be done about these waiting times as it’s just so unfair,” she added. “The health board can’t even give me a rough estimate for how long we’ll be waiting, even though her case has been classed as urgent and just one step down from skin cancer in terms of priority. There’s no end in sight which is heart-breaking.”

Riley’s eczema is everywhere

Aimee said their only option now is to try to raise the money they need to see a private consultant paediatric dermatologist based in Bristol. To donate please go here.

“It’s shocking we are forced to pay privately for a service that should be free to us. But she physically cannot be left to suffer like this any longer,” Aimee added.

According to Welsh Government figures, one in five Welsh people are on a list awaiting NHS treatment. In February, 691,885 were on patient pathways – more than 140,000 more than the same time last year.

Riley with her mum Aimee Bedwell
Riley with her mum Aimee Bedwell

There were 33,474 people on the NHS waiting list for dermatology treatments, around a third (9,827) of which had been on there for 36 weeks or more. This number has risen since the decision was made to halt all non-urgent appointments and procedures in March 2020 at the start of the pandemic, and ever since elective care has never fully recovered.

In April the government released its plan to tackle the waiting list backlog which included a pledge to eliminate one-year waits for treatment in most specialties by spring 2025. Health Minister Eluned Morgan said ‘Super Saturdays’ would be introduced to boost productivity over weekends, adding that incentives would be offered to NHS staff to encourage them to work longer hours.

Despite everything Riley has gone through, Aimee concluded that her daughter still goes around with a smile on her face most of the time. “She’s just a happy little soul even though she’s so uncomfortable.

“When she touches her skin she wins and cries, but other than that she’s the bubbliest little baby you could meet. How she can crack a smile through it I’ll never know.”

For more stories from where you live, visit InYourArea


Constipation Treatment Latest Trend – Carbon Valley Farmer and Miner


“Constipation Treatment Market” study by “marketreports.info” provides details about the market dynamics affecting the Constipation Treatment market, Market scope, Market segmentation and overlays shadow upon the leading Constipation Treatment market players highlighting the favorable competitive landscape and prevailing trends over the years.

This Constipation Treatment Report encloses comprehensive analysis on the Constipation Treatment market and are assessed through volume and value data validated on three approaches including top companies revenues. It concludes with precise and authentic market estimations considering all the parameters and market dynamics. Every crucial and determining detail for the development and restriction of the market is mentioned in fine points with solutions and suggestions that may affect the market in the near future. Segmentation of the market are studied specifically to give profound knowledge for supplementary market investments.

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The report “Constipation Treatment Market” gives varied description about the segmentation of the market on the basis of segmented Dosage, Route of Administration and Application, and leads with a descriptive structure of the trends and restrictions of the various segments and sub segments. It also provides the market size and estimates a forecast from the year 2022 to 2030 with respect to five major regions, namely; North America, Europe, Asia-Pacific (APAC), Middle East and Africa (MEA) and South & Central America. The report also provides exhaustive PEST analysis for all five regions after evaluating political, economic, social and technological factors impacting the Constipation Treatment market.

The Constipation Treatment report facilitates in determining and interpreting the key market players, portfolios with necessary information such as company profiles, components and services, financial information of past few years offered, key developments in past few years, that helps in constructing strategies to gain competitive advantage in the long run. The Constipation Treatment report also analyzes factors affecting Constipation Treatments market from both demand and supply side and further evaluates market dynamics effecting the market during the forecast period ie, drivers, restraints, opportunities, and future trend.

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Constipation Treatment Companies Mentioned: AstraZeneca (United Kingdom), Bayer AG (Germany), Sanofi (France), Sucampo Pharmaceuticals, Inc. (United States), Takeda Pharmaceuticals Company Limited (India), Ironwood Pharmaceuticals, Inc. (United States), Bausch Health (Canada), Abbott Laboratories (United States), Cosmo Pharmaceuticals NV (Ireland), Synergy Pharmaceuticals, Inc. (United States), Prestige Brands Holdings, Inc. (United States), Janssen Pharmaceutical Company (Belgium), Shionogi & Co., Ltd. (Japan)

By ApplicationInfantsChildrenBy MedicationOpioidsVitamin SupplementsAntiemeticsDrugsAntacidsDiureticsBy ConstipationNormal Transit ConstipationSlow Transit ConstipationDyssynergic Constipation

Key Elements that the Constipation Treatment report acknowledges:

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3Q Digital Acquires Inseev Interactive


CHICAGO–(BUSINESS WIRE)—3Q Digital, the disruptive growth marketing agency that transforms brands into market leaders, today announced its acquisition of Inseev Interactive (Inseev), a leading SEO agency based in San Diego.

The combination of Inseev’s deep technical understanding with 3Q Digital’s growth-minded approach to content and creator marketing will power the next evolution in SEO. The acquisition will also add enhanced scalability and content creation expertise to 3Q Digital’s existing SEO offerings.

Inseev, which was named “Best Large SEO Agency” at the 2021 US Search Awards, has assembled the digital marketing industry’s leading full-service SEO practice and brings extensive expertise in coordinating customized SEO services with full capabilities at scale. 3Q Digital will merge Inseev with its existing SEO team, immediately expanding its services. This will provide 3Q Digital clients with best-in-class organic search strategies designed to achieve top rankings across the entire search landscape, while also integrating with 3Q Digital’s other services to provide holistic digital experiences focused on unlocking limitless growth.

“SEO is a core growth marketing practice, and separate research from both 3Q Digital and from industry analysts show it as a critical channel for brands today. Inseev approaches SEO from an incredibly strategic lens – they have a unique and flexible model that can scale up or down depending on priorities,” said Rob Murray, CEO of 3Q Digital. “Inseev’s team of experts goes beyond just technical site fixes. They work with clients to develop exceptional custom content, and their link-building solution is world-class. We’re really excited to begin collaborating and sharing best practices – both teams have so much to learn from one another.”

The acquisition also adds a significant number of brands to 3Q Digital’s client roster, including Touch of Modern, Rothy’s and Layla Sleep. Inseev Founder and CEO Jimmy Page will be joining 3Q Digital in a Founder capacity. Additionally, Inseev’s Vice President of SEO Wesley Flippo joins the 3Q Digital Senior Leadership Team as SVP, SEO.

“Inseev is honored to become a part of an organization with the talent, leadership, culture, and history that 3Q Digital is so well-known for throughout the industry,” said Page. “We believe that Inseev is at the perfect point in our evolution to join forces with 3Q to create one of the world’s best SEO services. This acquisition gives us a large and multifaceted set of resources to take our best-in-class SEO offerings to the next level quickly and effectively.”

Madison Alley Global Ventures advised Inseev Interactive on this strategic M&A transaction.

About 3Q Digital

3Q Digital is one of the world’s largest independent digital growth marketing agencies. Verified by TechCrunch as an Expert Growth Marketing Agency, it has built an impressive portfolio of clients in a range of verticals through paid media, business strategy, decision sciences, creative, SEO, and content. 3Q Digital has ranked in both Ad Age’s and Inc.com’s Best Places to Work lists in 2020 and 2021, and was also recognized on Adweek’s Fastest Growing Agencies list in 2019.

About Inseev Interactive

Inseev Interactive is a privately owned performance digital marketing agency, heavily focused on search engine optimization and search engine advertising. Inseev was named “Best Large SEO Agency” in 2021 at the US Search Awards, and has naturally over its eight year history into a category leader. With over 70 team members throughout the United States, the company helps to grow brands from newly funded startups to Fortune 500 enterprises.

With Overdose Rates Continuing to Soar Here’s How to Find


Los Angeles, May 26, 2022 (GLOBE NEWSWIRE) — Los Angeles, California –

Los Angeles, CA – For people struggling to achieve long-term sobriety, surging drug-overdose rates are increasing the urgency of the need for treatment. Effective drug rehab programs can be found in Los Angeles at Muse Treatment, a center that has received hundreds of positive reviews from current and former patients.

Muse offers a comprehensive treatment of various substance use disorders, including treatment for fentanyl, a powerful synthetic opioid, and methamphetamine, a synthetic stimulant. These are the drugs that are feeding the surge in overdose deaths. According to preliminary data from the US Centers for Disease Control and Prevention (CDC), overdose deaths jumped by 15 percent in 2021. Almost 108,000 people died in the continuing crisis.

Deaths involving synthetic opioids, primarily fentanyl, rose from 58,000 to 71,000, while those associated with methamphetamine jumped from 25,000 to 33,000.

Before their dependence ends so tragically, addicts can find the support and therapy they need at Muse Treatment. Evidence-based therapies that treat the root causes of addiction are provided by caring and professional staff in comfortable surroundings that open the way to long-term sobriety.

The journey to sobriety usually begins with medical detox, which provides a safe, protected environment for withdrawing from the addictive substance. However, detox can be an uncomfortable time in the treatment process. Detox can even be dangerous if not managed by professionals. Muse offers expert supervision by medical professionals to ensure clients remain safe and as comfortable as possible.

Once detox is finished, the deeper work begins. Clients transition to inpatient (residential) rehab, where they work closely with therapists in a customized treatment program. This usually includes group and individual sessions using cognitive behavioral therapy and similar treatments. Once the inpatient rehab is complete, the next step is outpatient rehab, where treatment provides ongoing support as clients gradually transition back to day-to-day life outside the safety and security of the rehab.

Not everyone can commit to a residential rehab program. Sometimes work or family responsibilities make it difficult for a person to go away for treatment. In these cases, outpatient treatment can begin immediately after detox. Although inpatient care offers 24-7 support and eliminates outside pressures than can distract from the recovery process, clients receive the same high quality of care.

The goal of all treatment programs at Muse is to seek the source of the addiction, which is often an underlying emotional or psychological disorder that the person is trying to self-medicate with drugs or alcohol. When a person is diagnosed with substance use disorder and one or more mental health disorders, it is known as a dual diagnosis. According to research by the National Institute of Mental Health, about half of those who experience a substance use disorder have struggled with a co-occurring mental illness such as anxiety, depression, attention-deficit hyperactivity disorder, personality disorder, or schizophrenia.

For example, a person’s use of drugs or alcohol may be a coping mechanism to relieve symptoms of depression or anxiety. In this case, the treatment team may have to explore the client’s past to discover traumatic episodes or other events that may have led to the underlying disorder. It’s essential to treat both conditions together; If the addiction is resolved but not its underlying cause, the chance of a relapse is significantly increased.

Muse strongly believes that the environment also plays a critical role in addiction recovery. The physical surroundings at Muse are comfortable and relaxed, resembling a private home rather than a clinical treatment facility. Rooms offer modern conveniences, and recreational activities make treatment fun. Couples can attend therapy together while staying in same-sex accommodations. Clients can also bring their pets for the emotional support these loving companions provide.

For more information on seeking help before it’s too late, visit Muse Treatment or call (800) 426-1818.


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(800) 426-1818
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How Do You Ask Why You Got Cheated On? | PD Reader


The shock can be cataclysmic when you find out that your spouse or intimate partner cheated on you. You might feel sick to your stomach or actually throw up when you find that undeniable evidence.

As time goes on, you might feel like you’re in a kaleidoscope of memory. When did they start lying? Was the whole relationship ever real? What can I believe?

There are good and bad ways to ask the question: ‘Why?’

One of the first questions you’re going to ask is, “Why?” It’s natural to want to know. You have to take a step back and make sure that you’re asking that question for the right reasons.

The last thing that you need to do in this vulnerable moment is compound your feelings of betrayal with unwarranted feelings of guilt.

It’s helpful to ask “What could have caused this?” — it helps avoid turning the guilt on yourself.

Try to avoid asking things like, “What was wrong with me?” or “Why wasn’t I good enough?”

RELATED: My Best Friend Of 30 Years Compromised Us For A Woman He Knew For Six Months

To help you cope with this shocking moment, and the information that may follow your quesiton, please keep the following in mind:


2 hot topics that could impact 401(k) plans


(Photo: Shutterstock)

Just what is going on with Secure 2.0, whose official name is Securing a Strong Retirement Act of 2022? It’s a potential successor to the SECURE Act, but will the legislation pass? Will it further broaden and ease access to workplace retirement plans? And what’s the story on adding cryptocurrency assets to such plans?

Jennifer Gibbs Swets, a partner and director of relationship management at DWC – The 401(k) Experts Jennifer Gibbs Swets, a partner and director of relationship management at DWC – The 401(k) Experts.

Jennifer Gibbs Swets, a partner and director of relationship management at DWC – The 401(k) Experts in St. Paul, Minnesota, shares her take on these two hot topics. Sweets also sits on the contract relations for the American Society of Pension Professionals & Actuaries.

BenefitsPRO: What’s the latest on the passage of Securing a Strong Retirement Act of 2022 after the House in March gave a nearly unanimous blessing with a vote of 414 to 5?

We’re hoping that Congress keeps a focus on Secure 2.0 despite the fact that there are plenty of worthy distractions these days, not to mention plenty of partisan fighting going around. We’re hopeful optimism that Secure 2.0 will eventually pass, as there is strong bipartisan support for taking action that expands coverage for American bringing more people into the private retirement workers arena.

Round one, we all thought Secure 1.0 was going to pass in the summer of 2019, only to see it delayed until that December. It’s worth noting that even though this piece of legislation also enjoyed bipartisan support, it didn’t pass as a standalone bill – this language was incorporated into the Further Consolidated Appropriations Act, 2020. Round two, we could easily see Secure 2.0 stall until it finds itself part of a “must pass” bill working its way through Congress.

What provisions within Secure 2.0 are you particularly watching?

First, the potential changes for catch-up contribution. For 2022, the catch-up limit that applies to plan participants over age 50 is $6,500 per year. SECURE 2.0 would increase that catch-up limit to $10,000 per year once a participant gets to age 62 – with that $10,000 limit adjusted for COLA on an annual basis.

This increased catch-up opportunity comes with an asterisk though. Secure 2.0 proposes that all catch-up contributions would need to be Roth contributions as opposed to participants having the option to make these contributions as pre-tax deferrals. This type of change may not be well-received by high earners looking to save as they approach retirement and would also impact the nitty-gritty of plan administration and compliance testing. All in all, this proposed change may not be a complete surprise since Congress has to find a way to pay for the bill.

We’re also interested in the provision that would enable employers to match, within the retirement plan, student loan payments made by employees. This is great from a coverage standpoint, bringing more American workers into the private retirement plan system sooner, but it will also require some strategic thought on how to roll this out from an administrative standpoint. Regardless of those logistical pieces, we love that this expands the number of participants who may receive contributions under 401(k) plans.

The other item that we’re all paying close attention to is related to the long-term part-time employee provision that requires those who work 500 hours for three years in a row to be covered by a plan (for 401(k) purposes ). Secure 2.0 proposes a change from three years to two years for this mandatory coverage. Once again we have a scenario where we’re looking forward to expanded coverage of American workers, but we’re anxious to see regulatory guidance on exactly how this provision – whether two years or the current three-year provision – will be applied.

Tell me your thoughts on including cryptocurrency assets in 401(k) plans.

It’s a timely topic that’s generating a lot of talk right now. Whether you love the idea or not, getting more folks talking about retirement plans, debating fiduciary responsibilities, and taking a hard look at participants’ savings opportunities is a good thing. That said, from a fiduciary standpoint, cryptocurrency seems – at the moment – ​​a risky choice.

In March, the Department of Labor’s Employee Benefits Security Administration issued a release that cautions plan fiduciaries to “exercise extreme care” before they consider adding a cryptocurrency option to a 401(k) plan’s investment menu for plan participants. Regardless of any personal viewpoints on crypto, as a plan fiduciary I’m inclined to play it safe and follow that advice. Will that be the long term standing of EBSA? Maybe not, as Congress and the SEC seek to implement increased regulations on crypto.

Plan fiduciaries have a duty to ensure that the investment opportunities for their plan are monitored and to act with prodence regarding the appropriateness of investments offered. This feels like a challenge when it comes to crypto, which is where I think EBSA was coming from in March.

There’s a lot of partisan activity related to crypto in retirement plans with some saying EBSA has overreached with their compliance assistance release. I can appreciate differing viewpoints, the importance of diversification of assets, and a willingness to explore new investment opportunities for plan participants – these are all relevant and discussion-worthy. For me though, with the DOL having jurisdiction over plan fiduciaries, I think there’s value in heeding their advice and watching how crypto in plans evolves.

How to tell the difference


Fact checked on May 26, 2022 by Vivianna Shields, a journalist and fact-checker with experience in health and wellness publishing.

For the past two years, COVID-19 has coincided with allergy seasons—and most recently, with the virus’ Omicron variant (and its BA.2 and BA.2.12.1 subvariants), it’s more difficult to distinguish between the two.

With Omicron and its subvariants specifically—due to increased exposure to COVID-19 through vaccination or prior illness, or other variables—the virus generally causes more mild disease. Though symptoms don’t stray too far from those typically associated with COVID-19 in general, Omicron and its subvariants, can look a lot like the common cold, and even seasonal allergies.

Allergy and [Omicron] symptoms may mimic one another,” Jeffrey Dlott, MD, senior medical director at Quest Diagnostics, told Health. “Because of this, someone may confuse COVID symptoms for allergy symptoms and not take the proper precautions to reduce spread.”

Here’s what to know about how similar Omicron symptoms can look compared to allergies, and steps to take to confirm either diagnosis.

Though COVID-19 and allergies are caused by significantly different things—the SARS-CoV-2 virus and airborne substances like pollen, respectively—the two can present similarly. Upper respiratory symptoms like nasal congestion, sneezing, coughing, headache, and tiredness can show up with both conditions.

But once you get past those common respiratory symptoms, the two conditions start to look different. “With Omicron or other viral illnesses, people tend to feel under the weather and don’t feel well, but allergies don’t really give you that feeling,” Judith Berger, MD, director of the division of infectious diseases at SBH Health System in Bronx, New York , told Health. “Allergies also tend to not give you a fever or muscle aches.”

Fever specifically is a key indicator that you may have COVID-19 instead of allergies, according to Scott Fedlman, MD, PhD, an assistant professor of clinical medicine in the division of allergy and immunology at the University of Pennsylvania Health System. That’s because fever, or a rise in body temperature, is one of the ways the body tries to fight off infection or illness—the body essentially makes itself inhospitable for viruses and bacteria to survive and multiply.

A sudden loss of taste and smell could tip you off to a COVID-19 infection more than allergies, too. “Allergies can cause some mild decrease in smell when your nose is stuffy,” said Dr. Feldman. “But the sudden loss of smell is less likely to be due to allergies.”

What might be due to allergies, however, are itchy or watery eyes—symptoms that are common with pet and seasonal allergies, but not with COVID-19, said Dr. Feldman.

If your symptoms alone have you on the fence about whether you’re dealing with omicron or allergies, there are other non symptom-based ways to help recognize the difference.

Allergy History

Patients who have allergies know they have allergies—there’s often a history of symptoms and certain exposures that people can recall, Jeanne Lomas, DO, Director of Allergy and Immunology at WellNow Allergy, told Health.

The timing can tip you off, too. According to Dr. Berger, people with a history of allergies tend to present symptoms around the same time each year and in the same situations.

But knowing you don’t have a history of allergies can help you out, as well. If you don’t typically experience seasonal allergies, and then suddenly develop cold-like symptoms, the condition is “more likely infectious than allergic,” said Dr. Feldman.

Unhelpful Allergy Medications

People who use medication to manage allergy symptoms may be able to distinguish between COVID-19 and allergies by narrowing down symptoms, said Dr. Berger.

Typically, allergy medications effectively treat symptoms like congestion, runny nose, and coughing—but they won’t treat other infection-based symptoms like body aches, fever, or loss of taste and smell.

“Allergy medicines will treat a few symptoms of congestion or runny nose” in people who have allergies, said Dr. Berger. “It doesn’t relieve the shortness of breath, extreme, [and] it doesn’t return your sense of smell and taste.”

COVID-19 Testing

If you are still unsure as to whether you have COVID-19 or allergies, it’s recommended to take a COVID-19 test, particularly if you have more COVID-specific symptoms.

“Testing is the best way to determine if someone has COVID or seasonal allergies,” said Dr. Dlot. This can be through an at-home antigen test or through a PCR test.

Sometimes, however, at-home antigen tests specifically may not be as sensitive in picking up COVID-19 infections. “A person with a low viral load may not test positive even if they have the virus, so it is always important to be cautious if you are experiencing symptoms.” In that situation, testing again in the next day or two can help confirm results further.

If you do test positive, even with milder COVID-19 symptoms, it’s important to follow guidance from the Centers for Disease Control and Prevention on proper isolation practices. That means staying at home for at least five days and until you’re fever-free for at least 24 hours. After that, you should continue to wear a well-fitting mask in public for five additional days.

The information in this story is accurate as of press time. However, as the situation surrounding COVID-19 continues to evolve, it’s possible that some data have changed since publication. While Health is trying to keep our stories as up-to-date as possible, we also encourage readers to stay informed on news and recommendations for their own communities by using the CDC, WHOand their local public health department as resources.

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Obesity alters molecular architecture of liver cells; repairing structure reverses metabolic disease | News


For immediate release: Wednesday, March 9, 2022

Boston, MA – Cells use their molecular architecture to regulate their metabolic functions, and repair diseased cells’ architecture to a healthier state that can also repair metabolism, according to a study led by Harvard TH Chan School of Public Health researchers.

“Chronic metabolic disease, which includes obesity, diabetes, and cardiovascular and liver diseases, is the biggest global public health problem,” said Gökhan Hotamışlıgil, James Stevens Simmons Professor of Genetics and Metabolism at Harvard Chan School and the director of the Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research. “The fundamental regulatory mechanism that we discovered can be used to evaluate the susceptibility—or resistance—of individuals to a disease state like obesity, and determine what steps, such as diet, nutrients, or fasting, will reduce, eliminate, or exacerbate these states. We can imagine a whole new array of therapeutic strategies targeting molecular architecture, similar to the restoration of an ailing building or preventing its deterioration.”

The study was published online on March 9, 2022, in Nature.

Led by researchers Güneş Parlakgül and Ana Paula Arruda at the Sabri Ülker Center, the study compared liver samples from healthy, lean mice with samples from obese mice with fatty liver disease. Using multiple computational platforms—artificial intelligence, machine learning, deep learning, and neural networks—and high-resolution imaging using enhanced focused ion beam scanning electron microscopy, Parlakgül, Arruda, and colleagues from the Howard Hughes Medical Institute generated three-dimensional reconstructions of Specialized structures, called organelles, inside cells and made a comparative analysis of organelle architecture and organization of liver cells from lean and obese samples. Through these analyses, the team determined that obesity leads to dramatic alterations in subcellular molecular architecture, particularly in the endoplasmic reticulum (ER), an organelle involved in the creation and shaping of proteins and lipids.

The team then partially restored the ER’s structure using technologies that can repair molecules and proteins that can reshape cellular membranes—which also repaired the cells’ metabolism. The restored cells looked normal, controlled lipid and glucose metabolism much better, and remained stress free and more responsive to stimuli.

“The outcome was really striking—when the structure is repaired, so is the cell’s metabolism,” said Arruda. “What we are describing here is a whole new way of controlling metabolism by regulating molecular architecture, which is critical for health and disease.”

The images produced from this research are also the most detailed visualization to date of subcellular structures while the cells are still intact in their tissue environment. Other researchers have created similar imaging before, but mostly in single cells or in culture.

“High-resolution imaging and deep-learning-based analysis helped us to see that structural regulation of the intracellular environment and organelle architecture is a key component of metabolic adaptation. Targeting this regulation may hold therapeutic opportunities to treat metabolic diseases such as diabetes and fatty liver disease,” said Parlakgül.

For Hotamışlıgil, the visuals are astonishing. “I was first mesmerized with the complexity, beauty, and harmony of the constructions in the extremely crowded internal space of a cell,” he said. “This is like watching an artistic masterpiece while traveling into the center of a cell.”

This research was supported by the Sabri Ülker Center at Harvard Chan School.

Other Harvard Chan School researchers involved in this research included Erika Cagampan, Nina Min, Ekin Güney, Grace Yankun Lee, and Karen Inouye.

“Regulation of liver subcellular architecture controls metabolic homeostasis,” Güneş Parlakgül, Ana Paula Arruda, Song Pang, Erika Cagampan, Nina Min, Ekin Güney, Grace Yankun Lee, Karen Inouye, Harald F. Hess, C. Shan Xu, and Gökhan S Hotamışlıgil, Nature, March 9,2022, doi: 10.1038/s41586-022-04488-5

Image: Gökhan Hotamışlıgil/Sabri Ülker Center for Nutrient, Genetic, and Metabolic Research and Refik Anadol, Refik Anadol Studios, LA

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Harvard TH Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people’s lives—not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America’s oldest professional training program in public health.

Assessing Tobacco Exposure Among Former Smokers Eligible for Lung Cancer Screening


Results of a cross-sectional study showed former smokers eligible for lung cancer screening should be asked about recent tobacco use and exposure, while counseling about the harms of these 2 risk factors is warranted.

Results of a cross-sectional study of data from the 2013–2018 National Health and Nutrition Examination Survey (NHANES) revealed former smokers eligible for lung cancer screening (LCS) should be asked about recent tobacco use and exposure, while counseling about the harms of These 2 risk factors are warranted.

The findings were published in the Journal of General Internal Medicine.

Updated United States Preventive Services Task Force (USPSTF) recommendations indicate all adults aged 50 to 80 years with a 20 pack-year smoking history, and who currently smoke or have quit within the past 15 years should undergo LCS, authors wrote.

However, “while recommendations are clear for current smokers who present for LCS, the guidelines for counseling former smokers are not well defined,” they added.

In an effort to better understand former smoker behavior and identify high-risk former smokers who would benefit from targeted counseling at the time of LCS, researchers assessed deidentified NHANES data from 472 former smokers eligible for LCS.

All participants had smoked at least 100 cigarettes in their lifetime and did not currently smoke at the time of the survey. Main study outcomes were recent tobacco use and exposure. “Former smokers without recent tobacco use were classified as having recent tobacco exposure if their cotinine levels were greater than 0.05 ng/mL,” researchers explained.

Cotinine is a nicotine metabolite reflecting recent exposure. Any cotinine level above the race/ethnic cut points for tobacco use, or reported tobacco use in the past 5 days constituted “recent tobacco use.”

The majority of former smokers eligible for LCS were non-Hispanic White (82.7%), male (67.1), and had incomes more than 100% over the federal poverty level (83.3%).

Analyses revealed:

  • 1 in 5 former smokers eligible for LCS, totaling 1,416,485 adults when extracted to the US population, had recent tobacco use (21.4%; 95% CI, 15.8%-27.0%), with about a third each using cigarettes, e-cigarettes, or other tobacco products
  • While 17.5% of former smokers reported recent use of a tobacco product in the past 5 days, 19.7% had cotinine levels indicating active tobacco use above racial/ethnic cut points
  • Among former smokers without recent tobacco use, over half (53.0%; 95% CI, 44.6%-61.4%) had cotinine levels indicating recent tobacco exposure
  • Groups with a higher percentage of recent tobacco use than their counterparts include men, those who quit within the past 0–3 years, and those living with a household smoker

The high levels of recent tobacco use and exposure among former smokers eligible for LCS underscore the need for improved assessment and provider counseling, researchers wrote.

“Providers can use this data to inform strategies that improve assessments and target former smokers for counseling on their continued risk for tobacco-related addiction, disease, and mortality, particularly for cardiovascular and respiratory disease,” they said.

Further clarification on guidance for assessing tobacco use may also be helpful to minimize misclassification of current smokers, while asking about any use in the past month may be better at characterizing this patient population.

Environmental interventions may be particularly useful for these patients, authors added. “Patients may be counseled that there is no risk-free level of smoke exposure and advised to make a smoke-free home rule, not just for the continued risk of developing lung cancer but more immediately for cardiovascular health.”

Biomarker based exposure via cotinine levels may also be beneficial to better classify former smokers with secondhand smoke exposure; However, high sensitivity lab tests for cotinine may not be widely available.

“Future studies should assess whether including cotinine levels may change patient behavior and outcomes, and what the cost-effectiveness of this approach might be,” researchers said.

The self-reported nature of current smoking status marks a limitation to the analysis.


Hood-Medland EA, Dove MS, Tong EK. Assessment and counseling gaps among former smokers eligible for lung cancer screening in US adults. J Gen Intern Med. Published online April 26, 2022. doi:10.1007/s11606-022-07542-0